JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma
JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma
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DOI：
10.1016/j.intimp.2020.106706
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发表时间：
2020-09-01
影响因子：
5.6
通讯作者：
Huang, Peiyuan
中科院分区：
文献类型：
--
作者：
Liang, Feiguo;Liang, Hao;Huang, Peiyuan
肾透明细胞癌（KIRC）是全球最常见的癌症之一，总体预后不良。Janus激酶（JAK）家族在细胞机制如增殖、转移、侵袭和免疫中起重要作用。本研究通过各种门户网站，探讨JAK 3在KIRC中的表达及其临床意义。JAK 3在KIRC组织中表达显著上调。具有高JAK 3水平的KIRC患者显示出显著降低的无病生存率和总生存率。JAK 3表达与免疫细胞丰度和免疫生物标志物集之间存在显著相关性。富集功能分析显示基因功能与JAK 3显著相关，JAK 3主要通过多种癌症相关激酶、miRNA和转录因子与免疫应答、JAK-STAT信号通路、Ras信号通路相关。此外，我们还在KIRC中鉴定了JAK 3的几种激酶、miRNA或转录因子靶点。中枢基因（JAK 3、FCHO 1、INS 13、DEF 6和GPR 132）与几种著名的癌症相关通路的激活或抑制相关。我们的研究结果表明，JAK 3是一个潜在的生物标志物，并与KIRC的免疫浸润。
Kidney renal clear cell carcinoma (KIRC) is one of the most common cancers globally, with an overall poor prognosis. The Janus kinase (JAK) family plays an essential role in cellular mechanisms such as proliferation, metastasis, invasion, and immunity. In our study, various web-portals were used to explore the expression and clinical significance of JAK3 in KIRC. JAK3 expression was significantly up-regulated in KIRC tissues. Patients with KIRC having high JAK3 levels displayed a substantially decreased disease-free survival rate and overall survival rate. Significant correlations were obtained between JAK3 expression and the abundance of immune cells and immune biomarker sets. Enrichment function analysis revealed that gene function significantly correlated with JAK3, which was primarily associated with the immune response, JAK-STAT signaling pathway, Ras signaling pathway via several cancer-related kinases, miRNAs, and transcription factors. Moreover, we also identified several kinase, miRNA or transcription factor targets of JAK3 in KIRC. The hub genes (JAK3, FCHO1, INSl3, DEF6, and GPR132) were associated with the activation or inhibition of several famous cancer related pathways. Our results demonstrated that JAK3 is a potential biomarker and associated with immune infiltration in KIRC.