Differential effects of isoflavones on bone formation in growing male and female mice
Differential effects of isoflavones on bone formation in growing male and female mice
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DOI：
10.1016/j.metabol.2007.04.008
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发表时间：
2007-08-01
影响因子：
9.8
通讯作者：
Ishimi, Yoshiko
中科院分区：
文献类型：
--
作者：
Fujioka, Maiko;Sudo, Yumi;Ishimi, Yoshiko
很少有研究考察了在雄性和雌性动物的生长期，对骨形成的影响。在这项研究中，大豆黄酮或染料木黄酮对骨形成的影响进行了评估，在未成熟的男性和女性小鼠。将5周龄的雄性和雌性小鼠分别分为3组（每组n = 8）：对照组（C）饲喂对照饮食（AIN-93 G），大豆苷元组（D）饲喂含有0.08%纯大豆苷元的对照饮食，染料木黄酮组（G）饲喂含有0.08%纯染料木黄酮的对照饮食。4周后，雄性D组全身、腰椎和股骨的骨密度（BMD）明显高于C组。相反，女性D组的全身和股骨BMD显著低于C组。男性G组的整个股骨的BMD也显著高于C组。组织学分析显示，与C组相比，雄性D组和G组的骨形成率显著较高，而雌性D组的骨形成率较低。这些结果表明，大豆黄酮对生长期小鼠骨形成和BMD具有特异性的、性别上的双态性影响。(c)2007爱思唯尔公司All rights reserved.
Few studies have examined the effects of isoflavones on bone formation during growth period in male and female animals. In this study, the effects of daidzein or genistein on bone formation were assessed in immature male and female mice. Five-week-old male and female mice were divided respectively into 3 groups (n = 8 per group) as follows: control group (C) fed a control diet (AIN-93G), daidzein group (D) fed a control diet containing 0.08% pure daidzein, and genistein group (G) fed a control diet containing 0.08% pure genistein. After 4 weeks, the male D group had a significantly higher bone mineral density (BMD) in whole body, lumbar spine, and femur than did the C group. On the contrary, BMD of the whole body and femur in the female D group was significantly lower than that in the C group. The BMD of the whole femur in the male G group also was significantly higher than for the C group. Histologic analysis revealed that the bone formation rate was significantly higher in the male D and G groups, and lower in the female D group compared with the C group. These results suggest that daidzein has a specific, sexually dimorphic effect on bone formation and BMD during growth period in mice. (c) 2007 Elsevier Inc. All rights reserved.