HYPOGLYCAEMIC AND HYPOLIPIDAEMIC EFFECTS OF EMODIN AND ITS EFFECT ON L-TYPE CALCIUM CHANNELS IN DYSLIPIDAEMIC-DIABETIC RATS
HYPOGLYCAEMIC AND HYPOLIPIDAEMIC EFFECTS OF EMODIN AND ITS EFFECT ON L-TYPE CALCIUM CHANNELS IN DYSLIPIDAEMIC-DIABETIC RATS
复制标题
大黄素的降血糖、降血脂作用及其对血脂异常糖尿病大鼠L型钙通道的影响。
DOI：
10.1111/j.1440-1681.2008.05051.x
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Yang, Bao-Feng
中科院分区：
文献类型：
--
作者：
Zhao, Xiao-Yan;Qiao, Guo-Fen;Yang, Bao-Feng
本研究的目的是评价20，40和80 mg/kg/d大黄素对血脂异常糖尿病大鼠L型钙通道的影响每日给予大黄素2周后，血糖、血清总胆固醇、甘油三酯、游离脂肪酸和丙二醛（P < 0.05）。大黄素还能剂量依赖性地升高血脂异常糖尿病大鼠血浆超氧化物歧化酶活性（P < 0.05）。免疫荧光染色和逆转录-聚合酶链反应结果显示，3个剂量的大黄素治疗后，胰腺和心脏L型钙通道的表达均有不同程度的恢复，提示大黄素具有降糖和调脂作用，其机制部分涉及上调血脂异常糖尿病大鼠胰腺和心脏L型钙通道的表达。
The aim of the present study was to evaluate the hypoglycaemic and hypolipidaemic effects of 20, 40 and 80 mg/kg per day emodin and its potential effects on L-type calcium channels in dyslipidaemic-diabetic rats.Dyslipidaemic-diabetic rats were induced by a single intraperitoneal injection of streptozotocin (55 mg/kg) after intragastric administration of a high-fat diet for 2 weeks.Daily administration of emodin for 2 weeks resulted in a significant dose-dependent reductions in blood glucose, serum total cholesterol, triglycerides, free fatty acids and malonaldehyde (P < 0.05) in dyslipidaemic-diabetic rats compared with vehicle-treated dyslipidaemic-diabetic rats. In addition, emodin caused dose-dependent increases in plasma superoxide dismutase activity in dyslipidaemic-diabetic rats (P < 0.05). Immunofluorescent staining and reverse transcription-polymerase chain reaction showed that the expression of L-type calcium channels in the pancreas and heart was restored, to different extents, by the three doses of emodin treatment.The results of the present study suggest that emodin has antidiabetic and lipid-modulating effects that involve, in part, upregulation of L-type calcium channel expression in the pancreas and heart in dyslipidaemic-diabetic rats.