Cleaning microarray expression data using Markov random fields based on profile similarity

Cleaning microarray expression data using Markov random fields based on profile similarity
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使用基于轮廓相似性的马尔可夫随机场清理微阵列表达数据

DOI:
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发表时间:
2005
期刊:
ACM Symposium on Applied Computing
影响因子:
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通讯作者:
Kiyoko F. Aoki
Kiyoko F. Aoki
中科院分区:
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文献类型:
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作者:
R. Wan;Hiroshi Mamitsuka;Kiyoko F. Aoki

文献摘要

被引文献

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提出了一种去除基因芯片表达数据中噪声的方法。虽然其他方法要么集中在图像处理阶段,或将归一化技术应用到所得到的微阵列原始表达值,我们介绍了一种基于马尔可夫随机场的数据集的方法。清洁过程由具有相似表达谱的基因指导。结果,使用基因的生物相似性进行数据清洗。
This paper proposes a method for cleaning the noise found in microarray expression data sets. While other methods either concentrate on the image processing phase, or apply normalization techniques to the resulting microarray raw expression values, we introduce a method based on Markov random fields for the data set. The cleaning process is guided by genes with similar expression profiles. As a result, data cleaning is conducted using biological similarity of genes.