OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset [published erratum appears in J Exp Med 1991 Apr 1;173(4):1037]
OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset [published erratum appears in J Exp Med 1991 Apr 1;173(4):1037]
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OX-22high CD4 T 细胞诱导多器官病理消耗性疾病：通过 OX-22low 亚群进行预防[已发表的勘误表出现在 J Exp Med 1991 年 4 月 1 日；173(4):1037]
DOI：
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发表时间：
1990
影响因子：
15.3
通讯作者：
Don Mason
中科院分区：
文献类型：
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作者：
Fiona Powrie;Don Mason
先天性无胸腺大鼠注射来自同源正常胸腺供体的CD45RB高CD4+ T细胞后，发生了严重的消耗性疾病，并在肝、肺、胃、甲状腺和胰腺中出现炎性浸润。相比之下，CD45RB低CD4+ T细胞的受体保持良好，并继续增加体重。给予未分级的CD4+ T细胞的动物，即，大约三分之二的CD45RB高和三分之一的CD45RB低的混合物，被保护免于消耗性疾病，并且器官特异性炎症的发生率与在单独的CD45RB高细胞的接受者中发现的相比大大降低。数据表明，后一个亚群的CD4+ T细胞具有自身攻击性的潜力，在正常动物中被CD45RB低CD4+表型的细胞抑制。在这种免疫调节机制的故障的可能后果进行了简要讨论。
Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting disease with inflammatory infiltrates in liver, lung, stomach, thyroid, and pancreas. In contrast, recipients of CD45RBlow CD4+ T cells remained well and continued to gain weight. Animals given unfractionated CD4+ T cells, i.e., a mixture of approximately two-thirds CD45RBhigh and one- third CD45RBlow, were protected from the wasting disease, and the incidence of organ-specific inflammation was much reduced compared with that found in recipients of CD45RBhigh cells alone. The data suggest that this latter subset of CD4+ T cells has autoaggressive potential that is inhibited in normal animals by cells of the CD45RBlow CD4+ phenotype. The possible consequences of a breakdown in this immunoregulatory mechanism are briefly discussed.