Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water.
Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water.
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DOI：
10.1039/c3ra46838k
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发表时间：
2014
期刊：
影响因子：
3.9
通讯作者：
Piletsky S
中科院分区：
文献类型：
--
作者：
Poma A;Guerreiro A;Caygill S;Moczko E;Piletsky S
我们报道了一种用于水中固相合成MIP NPs的自动化化学反应器的开发。操作参数由计算机控制，只需最少的操作人员干预。在本研究中，仅在4小时内就制备出了具有亚纳摩尔亲和力的抗胃蛋白酶A、胰蛋白酶和α-淀粉酶的“即用型”MIP NPs。
We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, “ready for use” MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and α-amylase in only 4 hours.