Optimal replication of poliovirus within cells.
Optimal replication of poliovirus within cells.
复制标题
脊髓灰质炎病毒在细胞内的最佳复制。
DOI：
10.1086/428295
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Tanaka,MarkM
中科院分区：
文献类型：
--
作者：
Regoes,RolandR;Crotty,Shane;Antia,Rustom;Tanaka,MarkM
我们构建了脊髓灰质炎病毒（一种原型RNA病毒）细胞内复制的数学模型，并使用现实的参数估计来描述病毒基因组拷贝数的增加。我们的初始模型基本上是一个指数增长模型，我们还考虑修改这个模型，以考虑资源利用率。在实验系统中观察到的病毒复制动态饱和可以用病毒大量使用资源来解释。然后，我们使用我们的模型来考虑脊髓灰质炎病毒生长的优化条件。有趣的是，如果脊髓灰质炎病毒优化了其在细胞内的复制，那么预测的正链与负链的比例接近于实际观察到的比例。我们从生活史特征的演变来解释我们的发现。
We construct a mathematical model of the within‐cell replication of poliovirus, a prototypic RNA virus, and use realistic parameter estimates to describe the increase of copy number of the viral genome. Our initial model is essentially an exponential growth model; we also consider modifications of this model to account for resource utilization. The saturation of viral replication dynamics observed in experimental systems can be explained in terms of heavy resource use by the virus. We then use our models to consider the conditions under which the growth of poliovirus is optimized. Intriguingly, if poliovirus has optimized its replication within cells, the predicted ratio of positive to negative strands is close to what is actually observed. We interpret our findings in terms of the evolution of life‐history traits.