Cardiac mechanosensitivity and stretch-activated ion channels

Cardiac mechanosensitivity and stretch-activated ion channels
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DOI:
10.1016/s1050-1738(96)00119-3
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发表时间:
1997-01-01
影响因子:
9.3
通讯作者:
Sachs, F
Sachs, F
中科院分区:
医学2区
文献类型:
--
作者:
Bett, GCL;Sachs, F

文献摘要

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相似文献

机械敏感性是细胞普遍存在的一种特性,机械敏感离子通道(MSCs)被认为是转导细胞。在心脏中,MSCs可能会将心跳频率的变化解释为充盈的函数,以及引发牵张引起的心律失常(例如,在心肌梗死后)。影响MSCs的药物可能提供一类新的抗心律失常药物。(C)1997年,爱思唯尔科学公司。
Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs. (C) 1997, Elsevier Science Inc.