Aldehyde dehydrogenase 2 Glu504Lys variant predicts a worse prognosis of acute coronary syndrome patients.
Aldehyde dehydrogenase 2 Glu504Lys variant predicts a worse prognosis of acute coronary syndrome patients.
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醛脱氢酶2 Glu504Lys变异预测急性冠脉综合征患者预后较差
DOI：
10.1111/jcmm.13536
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发表时间：
2018-04
影响因子：
5.3
通讯作者：
Xu F
中科院分区：
文献类型：
--
作者：
Pan C;Zhao Y;Bian Y;Shang R;Wang JL;Xue L;Wei SJ;Zhang H;Chen YG;Xu F
乙醛脱氢酶2（ALDH 2）Glu 504 Lys变异是急性冠状动脉综合征（ACS）的独立危险因素。然而，关于该基因变异与ACS预后的关系尚缺乏研究。在前瞻性研究中，377例ACS患者根据基因型检测分为野生型（*1/*1）和突变型（*2/*2 + *1/*2）组。与野生型组相比，突变组的主要心脏不良事件（MACE）和心源性死亡发生率均较高（9.2% vs 21.0%，P = 0.002; 5.2% vs 12.2%，P = 0.026）;突变组的无MACE和无心源性死亡累积生存率明显较低。此外，突变基因型与MACE和心源性死亡风险显著增加相关（HR 2.443，95%CI：1.390 - 4.296，P = .002; HR 2.727，95%CI：1.303 - 5.708，P = .008）。提示ALDH 2 Glu 504 Lys变异可预测ACS患者预后不良。
Aldehyde dehydrogenase 2 (ALDH2) Glu504Lys variant was an independent risk factor for acute coronary syndrome (ACS). However, there are lacking researches about the relationship between the variant and prognosis of ACS. In the prospective study, 377 ACS patients were grouped into the wild‐type (*1/*1) and the mutation (*2/*2 + *1/*2) groups according to genotype detection. Compared with the wild‐type group, incidences of major adverse cardiac events (MACE) and cardiac death were both higher in the mutation group (9.2% vs 21.0%, P = .002; 5.2% vs 12.2%, P = .026); the MACE‐free and the cardiac‐death‐free cumulative survival rates were obviously lower in the mutation group. Moreover, the mutant genotypes were associated with significantly increased risk of MACE and cardiac death (HR 2.443, 95%CI: 1.390‐4.296, P = .002; HR 2.727, 95%CI: 1.303‐5.708, P = .008). These results suggested that ALDH2 Glu504Lys variant could predict a worse prognosis of ACS patients.
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影响因子：
5.4
作者：
Sun A;Zou Y;Wang P;Xu D;Gong H;Wang S;Qin Y;Zhang P;Chen Y;Harada M;Isse T;Kawamoto T;Fan H;Yang P;Akazawa H;Nagai T;Takano H;Ping P;Komuro I;Ge J
通讯作者：
Ge J
影响因子：
5.4
作者：
Mizuno Y;Hokimoto S;Harada E;Kinoshita K;Nakagawa K;Yoshimura M;Ogawa H;Yasue H
通讯作者：
Yasue H
影响因子：
10.8
作者：
Gomes, Katia M. S.;Campos, Juliane C.;Ferreira, Julio C. B.
通讯作者：
Ferreira, Julio C. B.
心肌梗死后心肌病进展过程中的醛负荷和醛脱氢酶 2 谱：Alda-1 的益处。
影响因子：
3.5
作者：
Gomes, Katia M. S.;Bechara, Luiz R. G.;Lima, Vanessa M.;Ribeiro, Marcio A. C.;Campos, Juliane C.;Dourado, Paulo M.;Kowaltowski, Alicia J.;Mochly-Rosen, Daria;Ferreira, Julio C. B.
通讯作者：
Ferreira, Julio C. B.
影响因子：
5.3
作者：
Zhu Y;Zhang D;Zhou D;Li Z;Li Z;Fang L;Yang M;Shan Z;Li H;Chen J;Zhou X;Ye W;Yu S;Li H;Cai L;Liu C;Zhang J;Wang L;Lai Y;Ruan L;Sun Z;Zhang S;Wang H;Liu Y;Xu Y;Ling J;Xu C;Zhang Y;Lv D;Yuan Z;Zhang J;Zhang Y;Shi Y;Lai M
通讯作者：
Lai M