Childhood cognitive function and adult psychopathology: associations with psychotic and non-psychotic symptoms in the general population
Childhood cognitive function and adult psychopathology: associations with psychotic and non-psychotic symptoms in the general population
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DOI：
10.1192/bjp.bp.111.102053
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发表时间：
2012-08-01
影响因子：
10.5
通讯作者：
Jones, Peter B.
中科院分区：
文献类型：
--
作者：
Barnett, Jennifer H.;McDougall, Fiona;Jones, Peter B.
背景儿童认知能力低下与未来精神分裂症的风险增加有关，但其与成人精神病样经历和其他精神病理学的关系尚不清楚。目的调查这种儿童时期的危险因素是否与成人亚临床精神症状表型(包括精神病样经历和一般精神病态)相同。在8岁、11岁和15岁时，使用与年龄相适应的语言和非语言认知测试的组合来评估认知能力。在53岁时，2918名参与者使用精神病筛查问卷中的四个条目自我报告类精神病经历，并使用一般健康问卷(GHQ-28)的量表版本评估一般精神疾病发病率。结果22%的参与者报告类精神病经历，并与其他精神病理学高度共存。他们在成人中的存在与8岁和15岁时儿童认知测试成绩较差显著相关，而在11岁时略有关联。相反，在校正了精神病样经历后，高GHQ得分与较差的童年认知并不相关。结论精神病性和非精神病性精神病症状在普通人群中高度共存。童年认知能力低下是中年精神病样经历的风险因素；这些现象可能是由早期神经发育变化驱动的表型表达连续体的一个结束。
BackgroundLower cognitive ability in childhood is associated with increased risk of future schizophrenia, but its relationship with adult psychotic-like experiences and other psychopathology is less understood.AimsTo investigate whether this childhood risk factor is shared with adult subclinical psychiatric phenotypes including psychotic-like experiences and general psychiatric morbidity.MethodA population-based sample of participants born in Great Britain during 1 week in March 1946 was contacted up to 20 times between ages 6 weeks and 53 years. Cognition was assessed at ages 8, 11 and 15 years using a composite of age-appropriate verbal and non-verbal cognitive tests. At age 53 years, psychotic-like experiences were self-reported by 2918 participants using four items from the Psychosis Screening Questionnaire and general psychiatric morbidity was assessed using the scaled version of the General Health Questionnaire (GHQ-28).ResultsPsychotic-like experiences were reported by 22% of participants, and were highly comorbid with other psychopathology. Their presence in adults was significantly associated with poorer childhood cognitive test scores at ages 8 and 15 years, and marginally so at age 11 years. In contrast, high GHQ scores were not associated with poorer childhood cognition after adjustment for the presence of psychotic-like experiences.ConclusionsPsychotic and non-psychotic psychopathologic symptoms are highly comorbid in the general population. Lower childhood cognitive ability is a risk factor for psychotic-like experiences in mid-life; these phenomena may be one end of a continuum of phenotypic expression driven by variation in early neurodevelopment.