Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges.
Immune interaction between respiratory syncytial virus infection and allergen sensitization critically depends on timing of challenges.
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DOI：
10.1086/324429
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发表时间：
2001-12
期刊：
影响因子：
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通讯作者：
R. Peebles;K. Hashimoto;R. Collins;K. Jarzecka;J. Furlong;D. Mitchell;J. Sheller;B. Graham
中科院分区：
文献类型：
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作者：
R. Peebles;K. Hashimoto;R. Collins;K. Jarzecka;J. Furlong;D. Mitchell;J. Sheller;B. Graham
严重呼吸道合胞病毒（RSV）感染被假设为过敏和哮喘发生的危险因素，但人类流行病学研究尚未得出结论。通过使用RSV感染和卵清蛋白过敏致敏的良好表征的鼠模型，测试先前严重RSV感染对肺过敏性炎症反应和气道高反应性（AHR）的发展的影响。还评价了先前过敏性致敏对RSV诱导的疾病的影响，如通过体重减轻测量的。过敏致敏前RSV感染可降低过敏原诱导的AHR、肺组织中白细胞介素-13的产生和肺嗜酸性粒细胞增多。相反，RSV感染前的过敏性致敏增加了AHR，并降低了RSV相关的体重减轻和肺部干扰素-γ水平，但不改变病毒清除率。这些数据提供的证据表明，RSV相关的AHR发生在过敏反应的主机和过敏性炎症减少时，RSV感染之前。
Severe respiratory syncytial virus (RSV) infection has been hypothesized to be a risk factor for the development of allergy and asthma, but epidemiologic studies in humans have been inconclusive. By use of a well-characterized murine model of RSV infection and allergic sensitization with ovalbumin, the effect of a preceding severe RSV infection on the development of the pulmonary allergic inflammatory response and airway hyperresponsiveness (AHR) was tested. The impact of prior allergic sensitization on RSV-induced illness, as measured by weight loss, also was evaluated. RSV infection before allergic sensitization decreased allergen-induced AHR, production of interleukin-13 in lung tissue, and lung eosinophilia. In contrast, allergic sensitization before RSV infection increased AHR and decreased RSV-related weight loss and lung levels of interferon-gamma but did not alter viral clearance. These data provide evidence that RSV-associated AHR occurs in hosts with allergic responses and that allergic inflammation is diminished when preceded by RSV infection.