PREVENTION OF IRREVERSIBLE HEMORRHAGIC SHOCK WITH FIBRINOLYSIN
PREVENTION OF IRREVERSIBLE HEMORRHAGIC SHOCK WITH FIBRINOLYSIN
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DOI：
10.1097/00000658-196301000-00004
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发表时间：
1963-01-01
影响因子：
9
通讯作者：
DRAKE, DC
中科院分区：
文献类型：
--
作者：
HARDAWAY, RM;DRAKE, DC
材料和方法实验模型。将体重为 25 至 35 磅的成年杂种狗（无论性别）随机分为治疗组，并同时接受我们的标准化放血程序。该过程现在由先前描述的过程的修改组成。 5 技术变化中最重要的是在测量控制血压水平时从收缩压转换为平均压。此外，血液处理系统已转变为完全封闭、完全塑料和完全过滤的系统，以确保无菌，最大限度地减少凝血因子的表面活化，并消除小凝块重新输注的可能性。鉴于我们最近的变化，特别是因为这种方法尚未被描述，对对照动物的出血技术的逐步描述似乎是合理的39
Materials and Methods Experimental Model. Adult mongrel dogs in the weight range of 25 to 35 pounds and of either sex were randomized as to treatment groups and simultaneously subjected to our standardized bleeding procedure. This procedure now consists of a modification of the procedure previously described. 5 Significant among the changes in technic is the conversion from systolic to mean pressure in measuring control blood pressure levels. Also, the system of blood handling has been converted to a completely closed, completely plastic, and completely filtered system in order to in-sure sterility, minimize surface activation of clotting factors, andomit the possibility of small clot re-infusion. A step-by-step description of ouir hemorrhage technic in the control animal seems jtustified in view of our recent changes and particularly because this method had not been described 39