Increased neural response to peer rejection associated with adolescent depression and pubertal development
Increased neural response to peer rejection associated with adolescent depression and pubertal development
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DOI：
10.1093/scan/nst175
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发表时间：
2014-11-01
影响因子：
4.2
通讯作者：
Dahl, Ronald E.
中科院分区：
文献类型：
--
作者：
Silk, Jennifer S.;Siegle, Greg J.;Dahl, Ronald E.
对社会评价的敏感性被认为是抑郁症的潜在标志或危险因素，理论上也被认为随着青春期的成熟而增加。这项研究利用一种生态有效的范式来检验这一假设，即与健康对照组相比，患有严重抑郁障碍(MDD)的青少年在与社会信息的情感处理有关的腹侧脑区网络中，对同伴拒绝和接受的反应会发生变化。共有48名青少年(年龄11-17岁)，包括21名目前被诊断为MDD的青少年和27名年龄和性别匹配的对照组，在功能神经成像期间的模拟在线同伴互动中，从虚拟同龄人那里获得了受操纵的接受和拒绝反馈。与对照组相比，年轻MDD患者在双侧杏仁核、膝前扣带回、左侧前脑岛和左侧伏隔核中对排斥反应的激活程度明显增加。MDD和健康青年对接受的反应没有不同。青春期成熟较晚的年轻人在双侧杏仁核/海马旁回和尾状/膝下扣带前回对排斥反应的反应性也增加，当控制年龄时，这些影响仍然显著。研究结果表明，对同伴拒绝的反应增加是与青春期发展相关的正常发展过程，但在患有抑郁症的年轻人中尤其明显。
Sensitivity to social evaluation has been proposed as a potential marker or risk factor for depression, and has also been theorized to increase with pubertal maturation. This study utilized an ecologically valid paradigm to test the hypothesis that adolescents with major depressive disorder (MDD) would show altered reactivity to peer rejection and acceptance relative to healthy controls in a network of ventral brain regions implicated in affective processing of social information. A total of 48 adolescents (ages 11-17), including 21 with a current diagnosis of MDD and 27 age- and gender-matched controls, received rigged acceptance and rejection feedback from fictitious peers during a simulated online peer interaction during functional neuroimaging. MDD youth showed increased activation to rejection relative to controls in the bilateral amygdala, subgenual anterior cingulate, left anterior insula and left nucleus accumbens. MDD and healthy youth did not differ in response to acceptance. Youth more advanced in pubertal maturation also showed increased reactivity to rejection in the bilateral amygdala/parahippocampal gyrus and the caudate/subgenual anterior cingulate, and these effects remained significant when controlling for chronological age. Findings suggest that increased reactivity to peer rejection is a normative developmental process associated with pubertal development, but is particularly enhanced among youth with depression.