Long-Term Effects of Dimethandrolone 17β-Undecanoate and 11β-Methyl-19-Nortestosterone 17β-Dodecylcarbonate on Body Composition, Bone Mineral Density, Serum Gonadotropins, and Androgenic/Anabolic Activity in Castrated Male Rats
Long-Term Effects of Dimethandrolone 17β-Undecanoate and 11β-Methyl-19-Nortestosterone 17β-Dodecylcarbonate on Body Composition, Bone Mineral Density, Serum Gonadotropins, and Androgenic/Anabolic Activity in Castrated Male Rats
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DOI：
10.2164/jandrol.110.010371
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发表时间：
2011-03-01
影响因子：
--
通讯作者：
Hild, Sheri A.
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文献类型：
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作者：
Attardi, Barbara J.;Marck, Brett T.;Hild, Sheri A.
强效雄激素二甲雄龙17 β-十一烷酸酯（DMAU）和11 β-甲基-19-去甲睾酮17 β-十二烷基碳酸酯（11 β-MNTDC）正在开发中，用于男性雄激素替代疗法和激素避孕。它们可以口服或作为长效注射剂递送。在目前的研究中，他们对身体组成（瘦肉和脂肪质量百分比）的长期影响;骨矿物质密度（BMD）;血清促性腺激素水平;前列腺，精囊和提肛肌的重量进行了评估。对4周龄雄性大鼠进行假手术（完整）或去势（Cx），并在术后皮下给予载体（Cx，完整）、DMAU或11 β-MNTDC（每4周一次）;庚酸睾酮（TE）（每2周一次）;或睾酮（T）植入物治疗16周。随着时间的推移，体重存在显著差异，总体趋势为完整= Cx + T = Cx + TE > Cx + 11 β-MNTDC> Cx > Cx + DMAU。在第18周，使用Hologic软件的全身功能通过双能X射线吸收测定法评价大鼠。瘦体重百分比和BMD较低（P.05）。在Cx大鼠中观察到最高的体脂百分比。与Cx大鼠相比，只有DMAU和11 β-MNTDC治疗的大鼠具有较低的体脂百分比（P
The potent androgens dimethandrolone 17 beta-undecanoate (DMAU) and 11 beta-methyl-19-nortestosterone 17 beta-dodecylcarbonate (11 beta-MNTDC) are in development for androgen replacement therapy and hormonal contraception in men. They can be delivered either orally or as long-acting injectables. In the current study, their long-term effects on body composition (percentage lean and fat mass); bone mineral density (BMD); serum gonadotropin levels; and weights of the prostate, seminal vesicles, and levator ani muscle were assessed. Four-week-old male rats were sham-operated (intact) or castrated (Cx) and treated subcutaneously for 16 weeks postsurgery with vehicle (Cx, intact), DMAU, or 11 beta-MNTDC every 4 weeks; testosterone enanthate (TE) every 2 weeks; or a testosterone (T) implant. There were significant differences in body weights over time with a general trend of intact = Cx + T = Cx + TE > Cx + 11 beta-MNTDC > Cx > Cx + DMAU. At week 18, rats were evaluated by dual-energy x-ray absorptiometry using the whole-body function of the Hologic software. The percentage lean body mass and BMD were lower (P.05). The highest percentage body fat was observed in Cx rats. Only DMAU- and 11 beta-MNTDC treated rats had lower percentage body fat compared with Cx rats (P