Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment.
Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment.
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DOI：
10.1002/lio2.115
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发表时间：
2017-12
影响因子：
1.9
通讯作者：
Takeda N
中科院分区：
文献类型：
--
作者：
Fukushima M;Kitahara T;Oya R;Akahani S;Inohara H;Naganawa S;Takeda N
梅尼埃病（MD）是一种常见的内耳疾病，其特征是反复阵发性眩晕、波动性感音神经性听力损失和耳鸣。其病理学被定义为内耳内淋巴积水 (EH)，并且假设 EH 与 MD 的临床症状相关。我们展示了 MD 患者在治疗过程中体内 EH 的动态。前瞻性、单臂重复测量 11 名 MD 患者入组。所有受试者在治疗前后均前瞻性地接受了钆增强内耳磁共振（MR）成像和神经耳科测试。通过处理 MR 图像来定量评估 EH 的体积。所有MD患者均接受持续用药并随访12个月以上。所有患者的眩晕发作频率均下降，前庭功能下降至治疗前水平的 13-91%。治疗后EH与治疗前EH的体积比范围为1.01-3.22。治疗前EH的总音量与耳蜗症状病程和受影响耳朵的听力水平显着相关。 MD患者的EH在治疗期间随着内耳功能的恶化而纵向发展。至少在一定时期内，MD 的自然病程可能会随着 EH 的发展而进展。 2b.
Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Prospective, single‐arm repeated measures Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium‐enhanced inner ear magnetic resonance (MR) imaging and neuro‐otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13–91% of the pre‐treatment level. The volume ratio of post‐treatment EH‐to‐pre‐treatment EH ranged from 1.01–3.22. The total volume of pre‐treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. 2b.