Semiparametric modeling of labeled-cell kinetics, with application to isotope labeling of erythrocytes.
Semiparametric modeling of labeled-cell kinetics, with application to isotope labeling of erythrocytes.
复制标题
标记细胞动力学的半参数建模，应用于红细胞的同位素标记。
DOI：
10.1111/j.0006-341x.2002.00937.x
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发表时间：
2002
期刊：
影响因子：
1.9
通讯作者：
Vogel,JohnS
中科院分区：
文献类型：
--
作者：
Müller,Hans-Georg;Su,Chun-Lung;Dueker,StephenR;Lin,Yumei;Clifford,Andrew;Buchholz,BruceA;Vogel,JohnS
We propose a stochastic model for the kinetics of cells that have been tagged with a chemical label. The proposed model consists of two components: a parametrically specified distribution for the time to incorporation of the label into the cells and a nonparametric survival function reflecting the survival time of the label-cell combination. The target quantity of this modeling approach is the fraction of labeled cells among all cells, viewed as a function of time. Longitudinal measurements of this labeled-cell fraction are available from a recent experiment with folate-labeled red blood cells. The proposed semiparametric model is fitted to these data and some of the implications are explored. The proposed method also includes bootstrap-based inference.
