The role of the kidney in hypertension.
The role of the kidney in hypertension.
复制标题
DOI：
10.1001/jama.1996.03530440061038
复制
发表时间：
1996-05
期刊：
影响因子：
--
通讯作者：
A. W. Cowley;R. Roman
中科院分区：
文献类型：
--
作者：
A. W. Cowley;R. Roman
尽管有明确的证据表明高血压患者的肾功能发生了改变，但某些重要的问题仍未得到解决。最有争议的领域是观察到的肾功能变化是否是高血压的结果或疾病的主要基础。尽管几乎没有人怀疑高血压的长期后果是肾脏逐渐受损，但6条证据表明，肾功能在疾病发展之前就已改变，某种形式的肾功能不全对高血压的发展和维持至关重要。这些研究表明：（1）肾脏在血压的长期控制中起主导作用;（2）每种高血压实验模型的诱导都涉及一些降低肾脏排泄功能的策略，并且在高血压发展之前和没有更多全局变化的情况下，可以观察到某些变化，例如肾髓质血流量减少
DESPITE unequivocal evidence that renal function is altered in hypertension, certain important issues are unresolved. The most controversial area is whether the observed changes in renal function are a consequence of hypertension or the primary basis of the disease. Although there is little doubt that the kidney is progressively damaged as a longterm consequence of hypertension, 6 lines of evidence indicate that renal function is altered before the development of the disease and that some form of renal dysfunction is essential for the development and maintenance of hypertension. These studies demonstrate that (1) the kidney plays a dominant role in the long-term control of blood pressure; (2) the induction of every experimental model of hypertension involves some maneuver that reduces renal excretory function, and certain changes, such as reduction of renal medullary blood flow, can be observed before the development of hypertension and in the absence of more global changes