High DNA sequence diversity in pericentromeric genes of the plant Arabidopsis lyrata
High DNA sequence diversity in pericentromeric genes of the plant Arabidopsis lyrata
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DOI：
10.1534/genetics.107.085282
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发表时间：
2008-06-01
期刊：
影响因子：
3.3
通讯作者：
Charlesworth, Deborah
中科院分区：
文献类型：
--
作者：
Kawabe, Akira;Forrest, Alan;Charlesworth, Deborah
由于突变率的差异和自然选择的“搭便车”效应，预计不同位点的中性多样性会出现差异。与搭便车模型一致，重组非常低的果蝇染色体区域具有异常低的核苷酸多样性。我们比较了拟南芥（高度自交拟南芥的异交近亲）前五个着丝粒周围区域的多样性水平与正常重组区域。与公认的理论预测和果蝇中的模式相反，我们发现着丝粒周围基因普遍具有较高的多样性，这与拟南芥中的观察结果一致。我们的数据排除了着丝粒周围区域的平衡选择，这表明搭便车比着丝粒周围区域更强烈地降低了染色体臂的多样性。
Differences in neutral diversity at different loci are predicted to arise due to differences in mutation rates and from the "hitchhiking" effects of natural selection. Consistent with hitchhiking models, Drosophila melanogaster chromosome regions with very low recombination have unusually low nucleotide diversity. We compared levels of diversity front five pericentromeric regions with regions of normal recombination in Arabidopsis lyrata, an outcrossing close relative of the highly selfing A. thaliana. fit contrast with the accepted theoretical prediction, and the pattern in Drosophila, we found generally high diversity in pericentromeric genes, which is consistent with the observation in A. thaliana. Our data rule out balancing selection in the pericentromeric regions, suggesting that hitchhiking is more strongly reducing diversity in the chromosome arms than the pericentromere regions.