PRDM16: the interconvertible adipo-myocyte switch
PRDM16: the interconvertible adipo-myocyte switch
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DOI：
10.1016/j.tcb.2009.01.007
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发表时间：
2009-04-01
影响因子：
19
通讯作者：
Burrell, Maria A.
中科院分区：
文献类型：
--
作者：
Fruhbeck, Gema;Sesma, Pilar;Burrell, Maria A.
棕色和白色脂肪细胞以前被认为是来自相同的前体细胞，尽管在组织学和功能上不同。然而，最近的一项研究表明，转录调节因子正调控域16（PRDM16）的过度表达决定了棕色脂肪细胞从祖细胞，表达成肌细胞标志物的发展。令人惊讶的是，PRDM16从这些前体的损失不会导致白色脂肪细胞分化。因此，PRDM16控制骨骼肌成肌细胞和棕色脂肪细胞之间的双向细胞命运转换。
Both brown and white adipocytes were previously considered to be derived from the same precursor cell, despite being histologically and functionally different. However, a recent study shows that overexpression of the transcriptional regulator positive regulatory domain containing 16 (PRDM16) determines the development of brown adipocytes from a progenitor that expresses myoblast markers. Surprisingly, loss of PRDM16 from these precursors does not lead to white adipocyte differentiation. Thus, PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown adipocytes.