ELECTRON-MICROSCOPIC CHANGES IN HUMAN ESOPHAGEAL EPITHELIUM IN ESOPHAGITIS
ELECTRON-MICROSCOPIC CHANGES IN HUMAN ESOPHAGEAL EPITHELIUM IN ESOPHAGITIS
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DOI：
10.1002/path.1711290402
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发表时间：
1979-01-01
影响因子：
7.3
通讯作者：
LOGAN, KR
中科院分区：
文献类型：
--
作者：
HOPWOOD, D;MILNE, G;LOGAN, KR
在超微结构水平上，发炎的食管上皮表现出多种病变。这些包括线粒体损伤、细胞内水肿、膜涡和内质网扩张以及角化透明和角化不全颗粒的出现。基底膜显示从增厚到连续性丧失的变化。锚定原纤维增加。细胞之间的空间扩大，并含有不同数量的富含中性粘液物质的碎片。在发炎的上皮细胞中，膜包被颗粒比正常上皮细胞少。上皮内侵入细胞为淋巴细胞和中性粒细胞。
At the ultrastructural level the inflamed esophageal epithelium shows a variety of lesions. These include mitochondrial damage, intracellular edema, membrane whorls and dilation of the endoplasmic reticulum and the appearance of keratohyaline and parakeratosis granules. The basement membrane shows changes ranging from thickening to areas of loss of continuity. There is an increase in the anchoring fibrils. The spaces between the cells are enlarged and contain varying amounts of debris rich in neutral mucosubstances. There are less membrane-coated granules in the inflamed epithelium than in the normal. The intra-epithelial intrusive cells demonstrated were lymphocytes and neutrophil polymorphs.