Degradation mechanism of magnesium alloy stent under simulated human micro-stress environment
Degradation mechanism of magnesium alloy stent under simulated human micro-stress environment
复制标题
模拟人体微应力环境下镁合金支架的降解机制
DOI：
10.1016/j.msec.2017.12.001
复制
发表时间：
2018-03-01
影响因子：
7.9
通讯作者：
Li, Qinglin
中科院分区：
文献类型：
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作者：
Liu, Dexue;Hu, Shiwen;Li, Qinglin
本研究以WE43镁合金制成的血管支架为研究对象，将其放置在自主构建的专用物理模拟装置中。该装置为研究支架在动态环境中的降解提供了平台。Hank缓冲盐溶液模拟体液在支架内流动，不仅使支架受到腐蚀，而且对支架施加循环剪切应力，更接近人体血管内的微应力环境。此外，利用计算机数值模拟软件ANSYS Fluent 15.0建立流固耦合（FSI）模型，模拟血管内流动血液对支架施加的壁面剪应力（WSS）。结合数值模拟和物理模拟实验结果，研究了镁合金在类似人体血管环境中的降解机理。
In this study, a vascular stent made of WE43 magnesium alloy was used as a research object and placed in a special physical simulation device constructed independently. This device provided a platform for the study of the degradation of the stent in a dynamic environment. The simulated body fluid of Hank's buffered salt solution flowing inside it would not only make the stent corroded but also apply cyclic shear stress to it, which get closer to the micro-stress environment in human blood vessels. In addition, by means of computer numerical simulation software, ANSYS Fluent 15.0, the fluid-structure interaction (FSI) model was established to simulate the wall shear stress (WSS) exerted by the flowing blood on stent in the blood vessel. Combined with the results of numerical simulation and physical simulation experiments, the degradation mechanism of magnesium alloy sent in an environment similar to the human blood vessels was studied.