Haematological abnormalities in neonatal necrotizing enterocolitis.
Haematological abnormalities in neonatal necrotizing enterocolitis.
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DOI：
10.3109/14767058.2012.715005
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Maheshwari A
中科院分区：
文献类型：
--
作者：
Song R;Subbarao GC;Maheshwari A
坏死性小肠结肠炎（NEC）是早产儿发病和死亡的主要原因，出生前32周的妊娠或出生体重小于1500克。在这篇文章中，我们审查血液异常与NEC。使用PubMed、EMBASE和Scopus数据库以及儿科学术学会年会上提交的摘要电子档案进行文献检索。血小板减少、弥散性血管内凝血、中性粒细胞计数升高或降低和溶血性贫血是NEC的常见事件。NEC与多种血液学异常相关，这些异常可能在肠粘膜损伤的发病机制中发挥直接或间接的作用。其中一些异常携带重要的预后信息。
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants born prior to 32 weeks gestation or with a birth weight less than 1500 grams. In this article, we review hematological abnormalities associated with NEC. A literature search was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies. Thrombocytopenia, disseminated intravascular coagulation, increased or decreased neutrophil counts, and hemolytic anemia are frequent events in NEC. NEC is associated with several hematological abnormalities, which may play a direct or indirect role in the pathogenesis of gut mucosal injury. Some of these abnormalities carry important prognostic information.