Analysis of Auditory Brain Stem Response with Lidocaine Injection into the Cerebrospinal Fluid in Rats
Analysis of Auditory Brain Stem Response with Lidocaine Injection into the Cerebrospinal Fluid in Rats
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DOI：
10.1177/000348949410301009
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发表时间：
1994-10
期刊：
影响因子：
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通讯作者：
Katsushi Yamada;T. Tsuzuku;K. Kaga;A. Uno
中科院分区：
文献类型：
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作者：
Katsushi Yamada;T. Tsuzuku;K. Kaga;A. Uno
在10只大鼠经颅蛛网膜下腔注射2%盐酸利多卡因诱导全脊麻后，记录听性脑干反应（ABR）。利多卡因13.3 ~ 40.0mg/kg注射后，ABR立即消失（4 min内）。消失开始于ABR的后期波。停药后，ABR再次出现，并从I波逐渐恢复到IV波。利多卡因对ABR的影响是可逆的，并在听神经延伸到中脑。
Auditory brain stem response (ABR) was recorded in 10 rats with total spinal anesthesia induced by injection of 2% lidocaine hydrochloride into the subarachnoid space through the skull. The ABR disappeared immediately (within 4 minutes) after the injection of 13.3 to 40.0 mg/kg lidocaine. The disappearance started with the later waves of the ABR. After cessation of the injection, the ABR reappeared and recovered progressively from wave I to wave IV. The effect of lidocaine on the ABR was reversible and extended in the acoustic nerve to the midbrain.