The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance.
The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance.
复制标题
DOI：
10.1186/1471-2334-5-89
复制
发表时间：
2005-10-20
影响因子：
3.7
通讯作者：
Clemens JD
中科院分区：
文献类型：
--
作者：
Agtini MD;Soeharno R;Lesmana M;Punjabi NH;Simanjuntak C;Wangsasaputra F;Nurdin D;Pulungsih SP;Rofiq A;Santoso H;Pujarwoto H;Sjahrurachman A;Sudarmono P;von Seidlein L;Deen JL;Ali M;Lee H;Kim DR;Han O;Park JK;Suwandono A;Ingerani;Oyofo BA;Campbell JR;Beecham HJ;Corwin AL;Clemens JD
在准备疫苗试验以评估对志贺氏菌病和霍乱的保护作用时，我们在雅加达北部的一个贫困地区进行了为期两年的社区监测研究，提供了有关该地区疾病负担的最新信息。 2001 年 8 月至 2003 年 7 月，我们在雅加达北部的一个贫困地区进行了一项为期两年的社区监测研究，以评估腹泻、志贺氏菌病和霍乱的负担。在参与的医疗保健提供者处，填写了病例报告表并从出现腹泻的病例中收集了粪便样本。婴儿腹泻（759/1 000/年）和霍乱（4/1 000/年）发病率最高。 5 岁以下男孩的腹泻发病率（387/1 000/年）显着高于 5 岁以下女孩（309/1 000/年；p < 0.001）。 1至2岁儿童志贺氏菌病发病率最高（32/1 000/年）。福氏志贺氏菌是分离出的最常见的志贺氏菌，其中 73% 至 95% 对氨苄青霉素、甲氧苄啶-磺胺甲恶唑、氯霉素和四环素具有耐药性，但仍对萘啶酸、环丙沙星和头孢曲松敏感。我们发现霍乱的总体发病率为 0.5/1 000/年。霍乱在儿童中最常见，1 岁以下儿童的发病率最高，为 4/1 000/年。在 154 株霍乱弧菌 O1 分离株中，89 株（58%）属于 El Tor Okawa 血清型，65 株（42%）属于 El Tor Inaba 血清型。 34% 的霍乱患者接受静脉补液，22% 需要住院治疗。副溶血性弧菌感染时有零星发现，但从 2002 年 7 月起有所增加。腹泻给雅加达的公共卫生造成了沉重的负担，尤其是对幼儿而言。志贺氏菌病的影响因抗菌素耐药性的威胁而加剧，而霍乱的影响则因其严重的表现而加剧。
In preparation of vaccines trials to estimate protection against shigellosis and cholera we conducted a two-year community-based surveillance study in an impoverished area of North Jakarta which provided updated information on the disease burden in the area. We conducted a two-year community-based surveillance study from August 2001 to July 2003 in an impoverished area of North Jakarta to assess the burden of diarrhoea, shigellosis, and cholera. At participating health care providers, a case report form was completed and stool sample collected from cases presenting with diarrhoea. Infants had the highest incidences of diarrhoea (759/1 000/year) and cholera (4/1 000/year). Diarrhea incidence was significantly higher in boys under 5 years (387/1 000/year) than girls under 5 years (309/1 000/year; p < 0.001). Children aged 1 to 2 years had the highest incidence of shigellosis (32/1 000/year). Shigella flexneri was the most common Shigella species isolated and 73% to 95% of these isolates were resistant to ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol and tetracycline but remain susceptible to nalidixic acid, ciprofloxacin, and ceftriaxone. We found an overall incidence of cholera of 0.5/1 000/year. Cholera was most common in children, with the highest incidence at 4/1 000/year in those less than 1 year of age. Of the 154 V. cholerae O1 isolates, 89 (58%) were of the El Tor Ogawa serotype and 65 (42%) were El Tor Inaba. Thirty-four percent of patients with cholera were intravenously rehydrated and 22% required hospitalization. V. parahaemolyticus infections were detected sporadically but increased from July 2002 onwards. Diarrhoea causes a heavy public health burden in Jakarta particularly in young children. The impact of shigellosis is exacerbated by the threat of antimicrobial resistance, whereas that of cholera is aggravated by its severe manifestations.
登录
查看更多内容
DOI：
10.4269/ajtmh.2001.65.788
发表时间：
2001-12-01
影响因子：
3.3
作者：
Simanjuntak, CH;Larasati, W;Corwin, AL
通讯作者：
Corwin, AL
影响因子：
2
作者：
Nazir, M;Pardede, N;Ismail, R
通讯作者：
Ismail, R
DOI：
10.1016/s0732-8893(02)00373-5
发表时间：
2002-06-01
影响因子：
2.9
作者：
Lesmana, M;Subekti, DS;Oyofo, BA
通讯作者：
Oyofo, BA
影响因子：
5.4
作者：
ESCOBAR, GJ;SALAZAR, E;CHUY, M
通讯作者：
CHUY, M
DOI：
10.1016/s0732-8893(02)00454-6
发表时间：
2002-11-01
影响因子：
2.9
作者：
Oyofo, BA;Lesmana, M;Corwin, AL
通讯作者：
Corwin, AL