Significance of mucin on the ocular surface.
Significance of mucin on the ocular surface.
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DOI：
10.1097/00003226-200203001-00005
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发表时间：
2002-03-01
期刊：
影响因子：
2.8
通讯作者：
Watanabe, Hitoshi
中科院分区：
文献类型：
--
作者：
Watanabe, Hitoshi
目的：综述黏蛋白在泪膜和眼表上皮中的重要性。
方法：总结关于角膜和结膜上皮以及杯状细胞产生的黏蛋白如何在眼表泪膜稳定性中起作用的信息。还参照眼表疾病讨论了眼表上皮产生的黏蛋白表达的变化。
结果：角膜和结膜上皮产生跨膜黏蛋白，如MUC1、MUC2和MUC4。相比之下，杯状细胞产生形成凝胶的分泌型黏蛋白MUC5AC。泪腺产生MUC7。在眼表，跨膜黏蛋白和分泌型黏蛋白之间的协同作用对于泪膜的稳定性是必要的。从眼睑睁开时起，眼表上皮的黏蛋白表达是协调的，并且在鳞状上皮化生和干眼症等情况下会发生改变。这种改变可能导致泪膜不稳定。
结论：眼表诱导产生黏蛋白可能促进泪膜的稳定性，更多的了解可能会促使开发一种治疗干眼症的新方法。
PURPOSE: To review the significance of mucin in the tear film and the ocular surface epithelium.METHODS: Summary of the information on how mucin derived from the corneal and conjunctival epithelia and from goblet cells plays a role in the stability of the tear film over the ocular surface. The change in mucin expression derived from the ocular surface epithelium is also discussed with reference to ocular surface disease.RESULTS: The corneal and conjunctival epithelia produce transmembrane mucins such as MUC1, MUC2, and MUC4. In contrast, goblet cells produce the gel-forming secretory mucin, MUC5AC. The lacrimal gland produces MUC7. On the ocular surface, cooperation between transmembrane mucin and secretory mucin is necessary for the stability of the tear film. The expression of mucin from the ocular surface epithelium is coordinated from the time of eyelid opening and is altered in conditions such as squamous metaplasia and dry eye. This alteration may result in instability of the tear film. CONCLU SION: The induction of mucin from the ocular surface may facilitate the stability of the tear film, and increased knowledge may lead to the development of a new modality for the treatment of dry eye.