Ancient DNA
Ancient DNA
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DOI：
10.1007/978-1-4939-9176-1
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发表时间：
2019
影响因子：
--
通讯作者：
B. Shapiro;M. Hofreiter
中科院分区：
文献类型：
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作者：
B. Shapiro;M. Hofreiter
在过去的十年里，我们对骨生物学的理解继续取得了巨大的进步。大多数罕见的遗传性骨病的基因已经确定，在多基因疾病的基因鉴定方面也取得了很大进展，如Paget病和骨质疏松。对转基因小鼠的研究已经发现了对骨骼有深远影响的其他基因。这些研究发现了许多新的途径，这些途径构成了骨细胞生物学家的研究重点，以了解这些基因和基因产物影响骨量和骨强度的机制。第二版骨研究协议包含了一系列协议，以帮助研究人员进行机制研究。在分子医学方法系列的传统中，这些章节是实用的实验室方案，应该使读者能够从头开始执行技术。
The last decade has continued to bring tremendous advances in our understanding of bone biology. The genes responsible for the majority of rare inherited bone disorders have been identified and much progress has been made in the identification of genes in polygenic disorders, such as Paget’s disease and osteoporosis. Studies of genetically modified mice have resulted in the identification of other genes with profound effects on bone. These studies have uncovered many new pathways which form the focus of research by bone cell biologists to understand the mechanisms by which these genes and gene products affect bone mass and bone strength.The second edition of Bone Research Protocols contains a catalogue of protocols to assist researchers in the pursuit of mechanistic studies. In the tradition of the Methods in Molecular Medicine series, the chapters are practical laboratory protocols that should enable the reader to carry out the techniques from scratch.