σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation.
σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation.
复制标题
Ø 受体拮抗剂对甲基苯丙胺引起的神经毒性的减弱与体温调节相关。
DOI：
10.1016/s1734-1140(13)71009-0
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Matsumoto,RaeR
中科院分区：
文献类型：
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作者：
Robson,MatthewJ;Seminerio,MichaelJ;McCurdy,ChristopherR;Coop,Andrew;Matsumoto,RaeR
甲基苯丙胺（Methamphetamine，METH）可引起啮齿类动物纹状体的体温升高和多巴胺能神经毒性。METH与σ受体相互作用，σ受体拮抗剂通常减轻METH诱导的高热和多巴胺能神经毒性。进行本研究是因为在两个实验中，用σ受体拮抗剂预处理未能减弱小鼠中的MET诱导的体温过高。这使我们能够确定是否σ受体拮抗剂（AZ 66和AC 927）的能力，以减轻METH-induced神经毒性依赖于他们的能力，以调节METH-induced hypertemia.MethodsMice处理使用重复给药的范例和体温记录。纹状体多巴胺测定一个星期post-treatment.ResultsThe数据表明，σ受体拮抗剂的能力，以减轻METH-induced多巴胺能神经毒性是链接到他们的能力，以阻止METH-induced hyperthermia.ConclusionThe能力的σ受体拮抗剂，以减轻METH-induced hyperthermia可能有助于其神经保护作用。
BackgroundMethamphetamine (METH) causes hyperthermia and dopaminergic neurotoxicity in the rodent striatum. METH interacts with σ receptors and σ receptor antagonists normally mitigate METH-induced hyperthermia and dopaminergic neurotoxicity. The present study was undertaken because in two experiments, pretreatment with σ receptor antagonists failed to attenuate METHinduced hyperthermia in mice. This allowed us to determine whether the ability of σ receptor antagonists (AZ66 and AC927) to mitigate METH-induced neurotoxicity depends upon their ability to modulate METH-induced hyperthermia.MethodsMice were treated using a repeated dosing paradigm and body temperatures recorded. Striatal dopamine was measured one week post-treatment.ResultsThe data indicate that the ability of σ receptor antagonists to attenuate METH-induced dopaminergic neurotoxicity is linked to their ability to block METH-induced hyperthermia.ConclusionThe ability of σ receptor antagonists to mitigate METH-induced hyperthermia may contribute to its neuroprotective actions.