Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus
Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus
复制标题
DOI：
10.1111/j.1399-0039.2008.01146.x
复制
发表时间：
2008-12-01
期刊：
影响因子：
--
通讯作者：
Avihingsanon, Y.
中科院分区：
文献类型：
--
作者：
Hirankarn, N.;Tangwattanachuleeporn, M.;Avihingsanon, Y.
本研究探讨了系统性红斑狼疮（SLE）易感性与干扰素α主要亚型IFNA1、IFNA2和IFNA5基因对病毒感染反应的关系。比较150例SLE患者和150例健康对照者各标记物的等位基因和基因型频率。本研究表明，IFNA5的A/A基因型（-2529）和IFNA1的G/G基因型（-1823）在隐性模型中与SLE疾病的保护作用相关[P-c = 0.03, P = 0.01，优势比(OR) = 0.4, 95%可信区间(CI) = 0.2-0.8, P-c = 0.09, P = 0.03, OR = 0.5, 95% CI = 0.2-0.9]。多因素降维分析显示，IFNA5（-2529）与IFNA1（-1823）基因之间存在边际交互作用，交叉验证一致性为10 / 10，预测误差为46%（排列p值= 0.05）。这是首次报道IFNA基因在SLE中的正相关，特别是特异性亚型IFNA1和IFNA5的作用。
In this study, the association between the systemic lupus erythematosus (SLE) susceptibility and the new candidate genes, IFNA1, IFNA2 and IFNA5 genes, major interferon-alpha subtypes, in responses to viral infection was investigated. Allele and genotype frequencies of each marker were compared between 150 SLE patients and 150 healthy control subjects. This study indicated that the A/A genotype of IFNA5 (-2529) and the G/G genotype of IFNA1 (-1823) were associated with the protection of SLE disease in a recessive model [P-c = 0.03, P = 0.01, odds ratio (OR) = 0.4, 95% confidence interval (CI) = 0.2-0.8 and P-c = 0.09, P = 0.03, OR = 0.5, 95% CI = 0.2-0.9, respectively). Multifactor dimensionality reduction analysis showed a marginal interaction between IFNA5 (-2529) and IFNA1 (-1823) gene, with a cross-validation consistency of 10 of 10 and a prediction error of 46% (permutation P-value = 0.05). This is the first report of positive association of IFNA gene in SLE, especially the role of specific subtypes IFNA1 and IFNA5.