ADVERSE-EFFECTS OF EXTRADURAL AND INTRATHECAL OPIATES - REPORT OF A NATIONWIDE SURVEY IN SWEDEN
ADVERSE-EFFECTS OF EXTRADURAL AND INTRATHECAL OPIATES - REPORT OF A NATIONWIDE SURVEY IN SWEDEN
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DOI：
10.1093/bja/54.5.479
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发表时间：
1982-01-01
影响因子：
9.8
通讯作者：
JACOBSEN, K
中科院分区：
文献类型：
--
作者：
GUSTAFSSON, LL;SCHILDT, B;JACOBSEN, K
瑞典麻醉师协会对硬膜外和鞘内阿片类药物的临床经验进行了一项全国性的回顾性调查。特别关注的是抑郁症的频率和类型。93个部门中有84个部门（90%）回答了问卷。直到1981年5月，已对. apprx给予硬膜外吗啡。硬膜外哌替啶220-450例，鞘内吗啡90-150例。23例硬膜外吗啡治疗患者（0.25-0.40%）和6例鞘内吗啡治疗患者（4-7%）报告了需要纳洛酮治疗的通气抑制。在22例患者中，硬膜外吗啡的管理被认为是一个主要的促成因素发生的抑郁症。这22名患者中只有2名在最后一剂阿片类药物（s.c.，i. m.，静脉内或硬膜外）。年龄≥70岁，接受胸硬膜外穿刺和排尿能力下降的患者似乎占多数。
The Swedish Society of Anesthetists conducted a nationwide retrospective survey of clinical experience with extradural and intrathecal opiates. Special interest was focused on the frequency and type of ventilatory depression. The questionnaire was answered by 84 of 93 departments (90%). Up to May 1981 extradural morphine had been given to .apprx. 6000-9150 patients, extradural pethidine to 220-450 and intrathecal morphine to 90-150 patients. Ventilatory depression requiring treatment with naloxone was reported in 23 patients treated with extradural morphine (0.25-0.40%) and in 6 given intrathecal morphine (4-7%). In 22 patients the administration of extradural morphine was considered as a major contributory factor for the occurrence of ventilatory depression. Only 2 of these 22 patients experienced ventilatory depression later than 6 h after the last dose of opiates (s.c., i.m., i.v. or extradural). Patients aged .gtoreq. 70 yr, those receiving thoracic extradural puncture and those with reduced ventilatory capacity seemed to be overrepresented.