Specific Associations Between Type of Childhood Abuse and Elevated C-Reactive Protein in Young Adult Psychiatric Rehabilitation Participants.
Specific Associations Between Type of Childhood Abuse and Elevated C-Reactive Protein in Young Adult Psychiatric Rehabilitation Participants.
复制标题
年轻成人精神康复参与者中童年虐待类型与 C 反应蛋白升高之间的特定关联。
DOI：
10.1093/ijnp/pyac065
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Nemeroff,CharlesB
中科院分区：
文献类型：
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作者：
Jabbi,MbembaM;Harvey,PhilipD;Kotwicki,RaymondJ;Nemeroff,CharlesB
背景早期的逆境，如童年的情感、身体和性创伤，与晚年的精神疾病和慢性疾病有关，包括炎症标志物的升高。尽管先前的研究表明慢性炎症功能障碍在几种疾病病因中起作用，但儿童创伤类型与晚年炎症和健康状况之间的具体联系尚不清楚。方法我们研究了住进精神病康复中心的患者(n = 280例)。用标准仪器收集儿童时期情感、身体和性创伤的自我报告历史。入院时，我们还评估了个体的体重指数，并采集血样检测炎症标志物C反应蛋白(CRP)水平。结果3种类型虐待的患病率均较高，均在21%以上。50%的样本有C反应蛋白升高，其中26%有临床意义的升高。我们发现，与情感或身体虐待的病史相比，儿童期性创伤病史与C反应蛋白升高有更明确的关联。当使用线性回归来检验体重指数的贡献时，这一结果是成立的。限制我们的样本相对年轻，平均年龄为27.2岁，少数民族和少数族裔参与者的代表性最低。结论儿童期的性创伤与儿童的情感和身体创伤有关，儿童期的性创伤可能导致炎症反应的升高，我们的发现证实了C反应蛋白与性虐待的相关性。未来的研究需要评估儿童期性创伤和日后健康状况较差之间的因果关系。
BackgroundEarly-life adversity such as childhood emotional, physical, and sexual trauma is associated with later-life psychiatric and chronic medical conditions, including elevated inflammatory markers. Although previous research suggests a role for chronic inflammatory dysfunctions in several disease etiologies, specific associations between childhood trauma types and later-life inflammation and health status are poorly understood.MethodsWe studied patients (n = 280) admitted to a psychiatric rehabilitation center. Self-reported histories of childhood emotional, physical, and sexual trauma were collected with a standard instrument. At the time of admission, we also assessed individuals’ body mass index and collected blood samples used to examine inflammatory marker C-reactive protein (CRP) levels.ResultsThe prevalence of all 3 types of abuse was relatively high at 21% or more. Fifty percent of the sample had elevations in CRP, with clinically significant elevations in 26%. We found that compared with a history of emotional or physical abuse, a history of childhood sexual trauma was more specifically associated with elevated CRP. This result held up when using linear regressions to examine the contribution of body mass index.LimitationOur sample was relatively young, with an average age of 27.2 years and minimal representation of ethnic and racial minority participants.ConclusionRelative to childhood emotional and physical trauma, childhood sexual trauma may lead to elevated inflammatory responses, as confirmed in our finding of an association between CRP and sexual abuse. Future studies need to assess the causal link between childhood sexual trauma and poorer health outcomes later in life.