Neurofeedback Control in Parkinsonian Patients Using Electrocorticography Signals Accessed Wirelessly With a Chronic, Fully Implanted Device.
Neurofeedback Control in Parkinsonian Patients Using Electrocorticography Signals Accessed Wirelessly With a Chronic, Fully Implanted Device.
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DOI：
10.1109/tnsre.2016.2597243
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发表时间：
2017-10
期刊：
影响因子：
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通讯作者：
Carmena JM
中科院分区：
文献类型：
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作者：
Khanna P;Swann NC;de Hemptinne C;Miocinovic S;Miller A;Starr PA;Carmena JM
帕金森病（PD）的特征是运动症状，如僵硬和运动迟缓，阻止正常运动。神经局部场电位（LFP）中的β带振荡（13-30 Hz）与这些运动症状相关。在这里，三名PD患者植入了治疗性脑深部神经刺激器，该刺激器还可以记录和无线传输神经数据，他们玩了一个神经反馈游戏，在游戏中，他们从感觉运动皮层区域调制他们的β波段功率。患者的β波段功率被实时传输，以更新他们试图驱动到提示目标的光标的位置。在玩游戏1-2小时后，所有三名患者都表现出高于机会水平的表现，无论皮层下刺激水平如何。这项研究首次展示了使用侵入性神经记录系统进行家庭神经反馈训练。未来的工作将探讨慢性神经反馈训练作为一种潜在的治疗工具，神经系统疾病的患者。
Parkinson’s disease (PD) is characterized by motor symptoms such as rigidity and bradykinesia that prevent normal movement. Beta band oscillations (13–30 Hz) in neural local field potentials (LFPs) have been associated with these motor symptoms. Here, three PD patients implanted with a therapeutic deep brain neural stimulator that can also record and wirelessly stream neural data played a neurofeedback game where they modulated their beta band power from sensorimotor cortical areas. Patients’ beta band power was streamed in real-time to update the position of a cursor that they tried to drive into a cued target. After playing the game for 1–2 hours each, all three patients exhibited above chance-level performance regardless of subcortical stimulation levels. This study, for the first time, demonstrates using an invasive neural recording system for at-home neurofeedback training. Future work will investigate chronic neurofeedback training as a potentially therapeutic tool for patients with neurological disorders.