The prevalence of human papilloma virus (HPV) infections in oral squamous cell carcinomas: A retrospective analysis of 88 patients and literature overview
The prevalence of human papilloma virus (HPV) infections in oral squamous cell carcinomas: A retrospective analysis of 88 patients and literature overview
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DOI：
10.1016/j.jcms.2014.04.022
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发表时间：
2014-10-01
影响因子：
3.1
通讯作者：
Ziebart, T.
中科院分区：
文献类型：
--
作者：
Krueger, M.;Pabst, A. M.;Ziebart, T.
除了吸烟和饮酒这两个口腔鳞状细胞癌(OSCC)的主要危险因素外，最近的研究发现，人乳头瘤病毒(HPV)感染是OSCC发生的另一个危险因素。在头颈部恶性肿瘤领域，口咽癌(OC)中HPV感染的患病率在不同的研究中高达84%。虽然HPV感染是这一地区的一个独立危险因素，但它在口腔癌发生中的独特作用仍不确定。在这项研究中，我们分析了88名在美因茨大学医学中心口腔颌面外科接受治疗的口腔鳞癌患者的HPV状态。采用DNA-聚合酶链式反应和p16蛋白免疫组织化学染色进行HPV状态分析，HPV阳性口腔鳞癌的发生率约为6%(5例)。3例发现HPV16/18亚型。HPV阳性和阴性患者在年龄、性别、吸烟和饮酒、部位和TNM水平方面均无显著差异。与其他专注于舌癌和腭癌的研究相反，口腔中HPV感染的患病率要低得多。因此，HPV感染在口腔癌的发生中可能起着次要的作用。(C)2014年欧洲颅颌面部外科协会。爱思唯尔有限公司出版。保留所有权利。
In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma (OSCC), recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for OSCC development. In the field of head and neck malignancies, the prevalence of HPV infections in oropharyngeal cancer (OC) ranges in different studies up to 84%. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of turnouts localized to the oral cavity remains still uncertain.In this study, we analysed the HPV status in 88 consecutive patients with OSCCs localized anterior of the palatoglossal arch who were treated in the Department of Oral and Maxillofacial Surgery at the University Medical Center Mainz. The HPV status analysis was performed using DNA-PCR and immunostaining of p16 protein.The prevalence of HPV-positive OSCCs was about 6% (5 patients). In 3 patients the HPV subtypes 16/18 were found. No significant differences between the HPV positive and negative patients regarding age, gender, smoking and alcohol consumption, localization and TNM level could be detected. Contrary to other studies focussing on cancers of the lingual and palatine tonsil, the prevalence of HPV infections was much lower in the oral cavity. Therefore HPV infection might play a less important role in oral carcinogenesis. (C) 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.