Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model
Temporal and spatial migration pattern of the subchondral bone plate in a rabbit osteochondral defect model
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DOI：
10.1016/j.joca.2012.06.008
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发表时间：
2012-10-01
影响因子：
7
通讯作者：
Madry, H.
中科院分区：
文献类型：
--
作者：
Orth, P.;Cucchiarini, M.;Madry, H.
目的：软骨下骨板上移与骨软骨修复有关。本研究的目的是在一年的自发性骨软骨修复的Lapine模型中定量监测软骨下骨板推进的顺序，并将这些发现与关节软骨修复相关联。设计：在兔滑车沟处制造标准化的圆柱形骨软骨缺损。在5个时间点确定软骨下骨重建模式。通过组织形态计量学分析确定软骨下骨板的移位和骨修复组织所占的面积。结果：软骨下骨重建模式：3周为圆柱形，6周为漏斗状，4个月和6个月为平面型，1年后为肥大型。在这个晚期时间点，骨软骨交界处比原来的水平前进了0.19[95%可信区间0.10-0.30]mm。关节软骨修复在术后4个月和6个月明显改善，但在1年后有所下降。软骨下骨板移位与潮标形成呈正相关(r=0.0001.47；P&t；0.44)，而与修复软骨总分无关(r=0.11；P>；0.44)。这种相关性的缺乏表明关节软骨修复和软骨下骨重建以不同的速度进行，软骨下骨板的推进不是该模型中关节软骨修复减少的原因。(C)2012年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: Upward migration of the subchondral bone plate is associated with osteochondral repair. The aim of this study was to quantitatively monitor the sequence of subchondral bone plate advancement in a lapine model of spontaneous osteochondral repair over a 1-year period and to correlate these findings with articular cartilage repair.Design: Standardized cylindrical osteochondral defects were created in the rabbit trochlear groove. Subchondral bone reconstitution patterns were identified at five time points. Migration of the subchondral bone plate and areas occupied by osseous repair tissue were determined by histomorphometrical analysis. Tidemark formation and overall cartilage repair were correlated with the histomorphometrical parameters of the subchondral bone.Results: The subchondral bone reconstitution pattern was cylindrical at 3 weeks, infundibuliform at 6 weeks, plane at 4 and 6 months, and hypertrophic after 1 year. At this late time point, the osteochondral junction advanced 0.19 [95% confidence intervals (Cl) 0.10-0.30] mm above its original level. Overall articular cartilage repair was significantly improved by 4 and 6 months but degraded after 1 year. Subchondral bone plate migration correlated with tidemark formation (r = 0.47; P < 0.0001), but not with the overall score of the repair cartilage (r = 0.11; P> 0.44).Conclusions: The subchondral bone plate is reconstituted in a distinct chronological order. The lack of correlation suggests that articular cartilage repair and subchondral bone reconstitution proceed at a different pace and that the advancement of the subchondral bone plate is not responsible for the diminished articular cartilage repair in this model. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.