Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population
Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population
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DOI：
10.2147/ndt.s138565
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发表时间：
2017-01-01
影响因子：
3.2
通讯作者：
Borkowska, Alina
中科院分区：
文献类型：
--
作者：
Bielinski, Maciej;Jaracz, Marcin;Borkowska, Alina
目的：肥胖患者普遍存在抑郁症状。奖赏回路中多巴胺信号的缺失可能会导致过度消费食物，导致肥胖和神经精神疾病，如抑郁症。本研究旨在探讨关联的基因编码DAT 1/SLC 6A 3和COMT与肥胖subjects.Participants和方法的抑郁症状的强度的多态性：抑郁症状的患病率和严重程度进行了评估，在一组364名肥胖患者使用贝克抑郁量表（BDI）和汉密尔顿抑郁量表（HDRS）。结果：DAT 1等位基因与抑郁症状和肥胖程度相关。9重复等位基因纯合子的受试者在BDI（P=0.022）和HDRS（P=0.00001）中得分更高，表明男女抑郁程度更高。该等位基因也与最高体重指数（BMI; P=0.001）相关。携带者的Val 158 Met等位基因的COMT得分较高的抑郁量表（BDI，P=0.0005; HRDS，P=0.002），并有最高的BMI values.Conclusion：在DAT 1和COMT基因的多态性与更大的强度在肥胖人群中的抑郁症状。
Objectives: Depressive symptoms are common among patients with obesity. Abnormalities in dopamine signaling involved in the reward circuit may ensue excessive consumption of food, resulting in obesity and leading to neuropsychiatric disorders such as depression. This study sought to investigate the association of polymorphisms in the genes encoding DAT1/SLC6A3 and COMT with the intensity of depressive symptoms in obese subjects.Participants and methods: Prevalence and severity of depressive symptoms were assessed in a group of 364 obese patients using the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale (HDRS). Genetic polymorphisms in DAT1 and COMT were evaluated in peripheral blood samples.Results: The results indicated an association between DAT1 alleles and depressive symptoms, as well as severity of obesity. Subjects homozygous for the nine-repeat allele scored higher in BDI (P=0.022) and HDRS (P=0.00001), suggesting higher intensity of depression in both sexes. This allele was also associated with the highest body mass index (BMI; P=0.001). Carriers of the Val158Met allele of COMT scored higher on both depression scales (BDI, P=0.0005; HRDS, P=0.002) and had the highest BMI values.Conclusion: Polymorphisms in the DAT1 and COMT genes are associated with a greater intensity of depressive symptoms in the obese population.