Maresin1 ameliorates acute lung injury induced by sepsis through regulating Th17/Treg balance
Maresin1 ameliorates acute lung injury induced by sepsis through regulating Th17/Treg balance
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Maresin1通过调节Th17/Treg平衡改善脓毒症引起的急性肺损伤
DOI：
10.1016/j.lfs.2020.117773
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发表时间：
2020-08-01
期刊：
影响因子：
6.1
通讯作者：
Yao, Shanglong
中科院分区：
文献类型：
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作者：
Xia, Haifa;Wang, Fuquan;Yao, Shanglong
感染引起的免疫平衡紊乱在脓毒症所致的多器官功能障碍中起决定性作用。Th17细胞和调节细胞(Treg)都是免疫系统的重要组成部分，在维持免疫动态平衡方面起着至关重要的作用。在这项研究中，我们探讨了一种新出现的特异性促炎介质Maresin1对脓毒症Th17/Treg平衡的影响，并探讨了其潜在的机制。本实验以雄性C57BL/6小鼠为模型，采用盲肠结扎和穿刺法建立脓毒症肺损伤模型，以验证马瑞菌素1的保护作用。我们的研究表明，在脓毒症所致的急性肺损伤过程中，Maresin1可以显著抑制过度的炎症反应，促进炎症消退，从而减轻肺损伤，改善肺功能。在脓毒症的早期阶段，伴随着maresin1对Th17/Treg平衡的调节。结果表明，在脓毒症早期，maresin1对Th1 7细胞有一定的调节作用，这与其对STAT3/RORFoxp3和STAT5/Foxp3信号通路的作用一致。我们的研究首次阐明了Maresin1与Th17/Treg平衡在脓毒症所致急性肺损伤中的关系。
The disturbance of the immune homeostasis caused by infection is decisive for multiple organ dysfunction caused by sepsis. Both the th17 cell and the regulatory cell(Tregs) are important components of the immune system and play a crucial role in maintaining immune homeostasis. In this study, we explored the effect of Maresin1, an emerging specific pro-inflammatory mediator, on the balance of Th17/Treg in sepsis, and investigated the underlying mechanism. We used the male C57BL/6 mice to establish the model of sepsis-induced lung injury by cecal ligation and puncture to verify the protective effect of Maresin1. Our study showed that Maresin1 could significantly inhibit the excessive inflammatory response and promote the inflammation regression in the process of sepsis-induced acute lung injury, thereby reducing lung damage and improving lung function. These effects were accompanied with the regulation of Maresin1 on the Th17/Treg balance in the early stages of sepsis. We demonstrated that Maresin1 has a certain effect on increasing the number of Treg and decreasing the number of Th17 cells in the early stages of sepsis, which is consistent with its effect on STAT3/RORγt and STAT5/Foxp3 signal pathways. Our study elucidated for the first time the relationship between Maresin1 and Th17/Treg balance in sepsis-induced acute lung injury.