Intermolecular asymmetric reductive aldol reaction of ketones as acceptors promoted by chiral Rh(Phebox) catalyst.
Intermolecular asymmetric reductive aldol reaction of ketones as acceptors promoted by chiral Rh(Phebox) catalyst.
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DOI：
10.1002/chin.200735090
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发表时间：
2007-03
期刊：
影响因子：
5.2
通讯作者：
T. Shiomi;H. Nishiyama
中科院分区：
文献类型：
--
作者：
T. Shiomi;H. Nishiyama
[反应：在过量丙酮存在下，用氢化硅烷和手性Rh（Phebox-ip）催化剂对肉桂酸酯进行共轭还原，显示出以极高的对映选择性（高达98%）提供相应的分子间还原羟醛产物。几个肉桂酸和巴豆酸底物和几个酮受体也进行了检查。
[reaction: see text] The conjugate reduction of cinnamates with hydrosilane and chiral Rh(Phebox-ip) catalyst in the presence of excess acetone is shown to provide the corresponding intermolecular reductive aldol product in extremely high enantioselectivity (up to 98%). Several cinnamates and crotonate substrates and several ketone acceptors were also examined.