Maculopapular eruption with enlarged macrophages in eight patients receiving G-CSF or GM-CSF
Maculopapular eruption with enlarged macrophages in eight patients receiving G-CSF or GM-CSF
复制标题
DOI：
10.1111/j.1468-3083.2004.00872.x
复制
发表时间：
2004-05-01
影响因子：
9.2
通讯作者：
García-Díez, A
中科院分区：
文献类型：
--
作者：
Alvarez-Ruiz, S;Peñas, PF;García-Díez, A
在过去的几年中，粒细胞和粒细胞巨噬细胞集落刺激因子（G-CSF 和 GMCSF）的使用越来越多，并且已报道了与这些治疗相关的数起皮疹。 1991 年，霍恩等人。描述了三名与 GM-CSF 输注时间平行的斑丘疹患者。其中两个病例的活检标本中巨噬细胞的数量和大小有所增加。从那时起，已经报道了几例显示这种组织病理学改变的病例，这种改变被认为是对 G-CSF 或 GM-CSF 反应的特征。尽管化疗后可能会出现巨噬细胞增大的斑丘疹，但我们发现细胞因子治疗开始后出现的这种皮疹提示有G-CSF和GM-CSF参与皮疹。我们描述了八例接受 G-CSF 或 GM-CSF 治疗的患者，这些患者出现了巨噬细胞增大的斑丘疹。
In the last years, granulocyte and granulocyte-macrophage colony-stimulating factors (G-CSF and GMCSF) are being increasingly used and several cutaneous eruptions have been reported in relation to these treatments. In 1991 Horn et al. described three patients with maculopapular eruption that paralleled the time of infusion of GM-CSF. Two of the cases showed an increase in the number and size of macrophages in the biopsy specimen. Since then, several cases have been reported showing this histopathological alteration that has been considered characteristic of reaction to G-CSF or GM-CSF. Although maculopapular eruption with enlarged macrophages can appear after chemotherapy treatment, we have found that the presentation of this eruption after the beginning of cytokine treatment is suggestive of the involment of G-CSF and GM-CSF in the eruption. We described eight cases of patients treated with G-CSF or GM-CSF that developed maculopapular eruptions with enlarged macrophages.