Bilateral pseudoangiomatous stromal hyperplasia tumors in axillary male gynecomastia: report of a case
Bilateral pseudoangiomatous stromal hyperplasia tumors in axillary male gynecomastia: report of a case
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男性腋窝男性乳房发育症双侧假性血管瘤性间质增生瘤一例报告
DOI：
10.1007/s00595-014-0892-6
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Mecker G. Moller
中科院分区：
文献类型：
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作者：
R. Vega;D. Pechman;Burco Ergonul;Carmen Gomez;Mecker G. Moller
假血管瘤性间质增生（PASH）是一种罕见的乳腺间质细胞的良性增生，具有由肌成纤维细胞排列的复杂模式的间隙。确切的病因尚不清楚，但已假定肌成纤维细胞对激素刺激的增殖反应。PASH是因其他原因切除的乳腺组织中相对常见的偶然发现，很少表现为局部肿块。自1986年首次描述以来，只有不到150例肿瘤性PASH病例报告。虽然PASH倾向于随着时间的推移而增长，但大多数病变通过手术切除而治愈，预后良好。我们报告一位44岁男性罹患双侧腋窝肿瘤性PASH的罕见病例。当考虑腋窝肿块的鉴别诊断时，对这种疾病的认识是很重要的。据我们所知，只有一例单侧腋窝肿瘤PASH的男性患者已被描述在英语，这是第一例PASH发生在男性双侧腋窝男性乳房发育。
Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign proliferation of breast stromal cells with a complex pattern of interanastomosing spaces lined by myofibroblasts. The exact etiology is still unknown, but a proliferative response of myofibroblasts to hormonal stimuli has been postulated. PASH is a relatively common incidental finding in breast tissue removed for other reasons and rarely manifests as a localized mass. Fewer than 150 cases of tumoral PASH have been reported since it was first described in 1986. Although PASH tends to grow over time, most lesions are cured by surgical excision and the prognosis is excellent. We report an unusual case of bilateral axillary tumoral PASH in a 44-year-old man. Awareness of this disease is important when considering the differential diagnosis of axillary masses. To our knowledge, only one other case of unilateral axillary tumoral PASH in a male patient has been described in English and this is the first case of PASH occurring in male bilateral axillary gynecomastia.