Role of clotting factors and fibrin structure in predisposition to atherothrombotic disease.
Role of clotting factors and fibrin structure in predisposition to atherothrombotic disease.
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DOI：
10.1586/14779072.3.6.1047
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发表时间：
2005-11-01
影响因子：
2
通讯作者：
Grant, Peter J
中科院分区：
文献类型：
--
作者：
Ajjan, Ramzi A;Grant, Peter J
动脉粥样硬化血栓性疾病是一种多因素疾病，继发于复杂的基因-环境相互作用。阻塞性血栓的形成代表动脉粥样硬化血栓形成过程的最后阶段，了解血栓形成的机制对于制定旨在降低该疾病死亡率和发病率的新预防和治疗策略至关重要。研究表明，最终的血块结构与动脉粥样硬化血栓性疾病的易感性之间存在重要的相关性。遗传和环境因素都会影响血栓的最终超微结构，进而影响个体患病的风险。本文回顾了确定血块结构所涉及的因素。还将讨论常用治疗药物在调节血块结构中的作用。
Atherothrombotic disease is a multifactorial disorder that develops secondary to a complex gene-environment interaction. The formation of an obstructive thrombus represents the final stage of the atherothrombotic process, and understanding the mechanisms involved in clot formation is essential in order to develop new preventive and therapeutic strategies aimed at decreasing mortality and morbidity from the disease. Studies have demonstrated an important correlation between final clot structure and predisposition to atherothrombotic disease. Both genetic and environmental factors contribute to the final ultrastructure of the clot, which, in turn, influences an individual's risk of the disease. This paper reviews the factors involved in determining clot structure. The role of commonly used therapeutic agents in modulating clot structure will also be discussed.