Short-term psychological impact of the BRCA1/2 test result in women with breast cancer according to their perceived probability of genetic predisposition to cancer
Short-term psychological impact of the BRCA1/2 test result in women with breast cancer according to their perceived probability of genetic predisposition to cancer
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DOI：
10.1038/bjc.2012.599
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发表时间：
2013-03-19
影响因子：
8.8
通讯作者：
Dolbeault, S.
中科院分区：
文献类型：
--
作者：
Bredart, A.;Kop, J. L.;Dolbeault, S.
背景：根据乳腺癌患者对癌症遗传易感性的感知概率，评估BRCA1/2基因检测结果对乳腺癌患者焦虑、抑郁、与癌症相关的思想侵入或回避以及对癌症风险的感知控制的影响。方法：243名BC女性（89%应答率）在首次遗传咨询（T1）后完成问卷调查，其中180名（66%）在获得BRCA1/2结果（T2）后再次完成问卷调查。评估了女性在T1时感知到的癌症遗传易感性概率与遗传学家计算出的估计值之间的差异。结果：总的来说，74%的女性接受了阴性无信息（NU）， 11%的BRCA1/2阳性，15%的未分类变异（UV）结果。在分层回归分析中，BRCA1/2阳性的女性（与NU或UV相比），T1时癌症遗传易感性的感知概率低于客观估计，T2时焦虑水平较低(β = 0.28； P
Background: The effect of BRCA1/2 gene test result on anxiety, depression, cancer-related thought intrusion or avoidance and perceived control over cancer risk was assessed in breast cancer (BC) patients, according to their perceived probability of genetic predisposition to cancer.Methods: Two hundred and forty-three (89% response rate) women with BC completed questionnaires after an initial genetic counselling visit (T1), of which 180 (66%) completed questionnaires again after receiving the BRCA1/2 results (T2). The discrepancy between women's perceived probability of cancer genetic predisposition at T1 and the geneticist's computed estimates was assessed.Results: In all, 74% of women received a negative uninformative (NU), 11% a positive BRCA1/2 and 15% an unclassified variant (UV) result. On hierarchical regression analysis, in women with a positive BRCA1/2 result (vs NU or UV), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted lower levels of anxiety at T2 (beta = 0.28; P