Risk factors for developing a cutaneous injection-related infection among injection drug users: a cohort study.
Risk factors for developing a cutaneous injection-related infection among injection drug users: a cohort study.
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DOI：
10.1186/1471-2458-8-405
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发表时间：
2008-12-09
影响因子：
4.5
通讯作者：
Kerr T
中科院分区：
文献类型：
--
作者：
Lloyd-Smith E;Wood E;Zhang R;Tyndall MW;Montaner JS;Kerr T
皮肤注射相关感染（CIRI），如脓肿和蜂窝织炎，在注射吸毒者（IDU）中是常见和可预防的。然而，CIRI的危险因素尚未在文献中得到很好的描述。我们试图在使用北美首个监督注射设施（SIF）的个体中描述当前CIRI的危险因素。采用广义线性混合效应模型，对2004年1月1日至2005年12月31日期间参加监督注射科学评估（SEOSI）队列的参与者中发生CIRI的相关因素进行了纵向分析。总共有1065名参与者符合这项研究的条件。在研究期间，CIRI参与者的比例保持在10%以下。在多变量广义线性混合效应模型中，女性(调整优势比（AOR) = 1.68[95%置信区间（CI）： 1.16-2.43]）、不稳定的住房（AOR = 1.49 [95% CI: 1.10-2.03]）、借用使用过的注射器（AOR = 1.60 [95% CI: 1.03-2.48]）、需要帮助注射（AOR = 1.42 [95% CI: 1.03-1.94]）和每天注射可卡因（AOR = 1.41 [95% CI: 1.02-1.95]）与CIRI风险增加相关。CIRI在本研究中IDU的一个子集中很常见，包括女性，每天注射可卡因，居住在不稳定的住房中，需要帮助注射或借用注射器。为了减轻与CIRI相关的发病率负担，需要针对包括社会和环境条件在内的一系列因素采取有针对性的干预措施。
Cutaneous injection-related infections (CIRI), such as abscesses and cellulitis, are common and preventable among injection drug users (IDU). However, risk factors for CIRI have not been well described in the literature. We sought to characterize the risk factors for current CIRI among individuals who use North America's first supervised injection facility (SIF). A longitudinal analysis of factors associated with developing a CIRI among participants enrolled in the Scientific Evaluation of Supervised Injecting (SEOSI) cohort between January 1, 2004 and December 31, 2005 was conducted using generalized linear mixed-effects modelling. In total, 1065 participants were eligible for this study. The proportion of participants with a CIRI remained under 10% during the study period. In a multivariate generalized linear mixed-effects model, female sex (Adjusted Odds Ratio (AOR) = 1.68 [95% Confidence Interval (CI): 1.16–2.43]), unstable housing (AOR = 1.49 [95% CI: 1.10–2.03]), borrowing a used syringe (AOR = 1.60 [95% CI: 1.03–2.48]), requiring help injecting (AOR = 1.42 [95% CI: 1.03–1.94]), and injecting cocaine daily (AOR = 1.41 [95% CI: 1.02–1.95]) were associated with an increased risk of having a CIRI. CIRI were common among a subset of IDU in this study, including females, those injecting cocaine daily, living in unstable housing, requiring help injecting or borrowing syringes. In order to reduce the burden of morbidity associated with CIRI, targeted interventions that address a range of factors, including social and environmental conditions, are needed.
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影响因子：
3.8
作者：
Tyndall, MW;Currie, S;Schechter, MT
通讯作者：
Schechter, MT
影响因子：
6
作者：
Strathdee, SA;Patrick, DM;OShaughnessy, MV
通讯作者：
OShaughnessy, MV
影响因子：
13.5
作者：
Miller, CL;Johnston, C;Schechter, MT
通讯作者：
Schechter, MT
影响因子：
1.4
作者：
Patrick, DM;Strathdee, SA;OShaughnessy, MV
通讯作者：
OShaughnessy, MV
影响因子：
4.4
作者：
Shannon, K;Ishida, T;Tyndall, MW
通讯作者：
Tyndall, MW