Development of minimally invasive microdialysis needle for continuous monitoring of biological substances
Development of minimally invasive microdialysis needle for continuous monitoring of biological substances
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开发连续监测生物物质的微创微透析针
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Y. Haga
中科院分区：
文献类型：
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作者：
Noriko Tsuruoka;K. Ishii;T. Matsunaga;R. Nagatomi;Y. Haga
生物物质的浓度可作为我们健康的指标。为了监测生物物质，开发了在表皮下组织中进行微透析的微创装置。微透析针具有带透析膜的流道。它是通过我们开发的非平面光加工工艺围绕细钢针制造的。由于额外应用了此过程，因此可以使用几种异形管和线材作为基础物质。使用小鼠进行动物实验。测量乳酸浓度作为生物物质之一。用该针成功收集了乳酸。
Concentrations of biological substances are useful as indicator of our health. In order to monitor biological substances, the minimally invasive device which does microdialysis in subepidermal tissue has been developed. Microdialysis needle has flow channel with dialysis membrane. It has been fabricated around a thin steel needle by our developed non-planer photofabrication process. Because this process is additionally applied, several shaped tubes and wires can be used as a base substance. Animal experiment was performed using mouse. Lactate concentration was measured as one of biological substance. Lactate was successfully collected with this needle.