Melatonin in older people with age-related sleep maintenance problems: A comparison with age matched normal sleepers
Melatonin in older people with age-related sleep maintenance problems: A comparison with age matched normal sleepers
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DOI：
10.1093/sleep/24.4.418
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发表时间：
2001-06-15
期刊：
影响因子：
5.6
通讯作者：
Arendt, J
中科院分区：
文献类型：
--
作者：
Baskett, JJ;Wood, PC;Arendt, J
研究目的：为了确定老年人与年龄相关的睡眠问题是否有显着较低的褪黑激素水平比可比的正常sleepers.Design：病例对照研究。设置：一个主要的城市人口，奥克兰，新西兰。参与者：65岁以上的人，谁要么睡眠正常，或与年龄相关的睡眠问题。参与者是通过媒体广告和当地利益团体招募的。最初的筛查是通过邮件（匹兹堡睡眠质量指数），然后在医院的日间诊所进行面谈。排除包括那些抑郁症，认知障碍，医疗和/或环境问题，这可能会损害sleep.Interventions：N/A测量和结果：血浆褪黑激素，6-sulphatoxymelatonin（aMT 6s）的代谢产物进行了测量，在尿液中的57个正常睡眠者，和53人与年龄相关的问题超过24小时，在三个等分试样：12：00-19：00小时，19：00-07：00小时，07：00-12：00小时。有明显的差异，自我报告的睡眠质量，但平均aMT 6s 24小时或总夜间排泄水平，或夜/日ratio.Conclusions：老年人与年龄相关的睡眠维持问题没有较低的褪黑激素水平比老年人报告正常睡眠没有差异。
Study Objectives: To determine whether older people with age-related sleep maintenance problems have significantly lower melatonin levels than comparable normal sleepers.Design: Case-control study.Setting: A largely urban population, Auckland, New Zealand.Participants: People over the age of 65 years, who either slept normally, or had age-related sleep maintenance problems. Participants were recruited through media advertising, and local interest groups. Initial screening was by mail (Pittsburgh Sleep Quality Index), followed by interviews at a hospital day clinic. Exclusions included those with depression, cognitive impairment, medical and/or environmental problems which might impair sleep.Interventions: N/AMeasurements and Results: A metabolite of plasma melatonin, 6-sulphatoxymelatonin (aMT6s) was measured in the urine of 57 normal sleepers, and 53 people with age-related problems over 24 hours in three aliquots: 12:00-19:00h, 19:00-07:00h, 07:00-12:00h. There were clear differences in self reported quality of sleep but no difference in mean aMT6s 24 hour or total night excretory levels, or night/day ratios.Conclusions: Older people with age-related sleep maintenance problems do not have lower melatonin levels than older people reporting normal sleep.