Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study
Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study
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DHEA 给药对健康年轻男性情景记忆、皮质醇和情绪的影响：一项双盲、安慰剂对照研究
DOI：
10.1007/s00213-005-0136-y
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发表时间：
2006-11-01
影响因子：
3.4
通讯作者：
McAllister-Williams, R. Hamish
中科院分区：
文献类型：
--
作者：
Alhaj, Hamid A.;Massey, Anna E.;McAllister-Williams, R. Hamish
理由：据报道，脱氢表雄酮 (DHEA) 可以增强啮齿类动物的认知能力，但在人类中的研究结果不一致。目的：本研究的目的是利用事件相关电位 (ERP) 技术研究健康年轻男性服用 DHEA 对情景记忆及其神经相关性的影响。方法：采用双盲、随机、交叉和平衡顺序设计，对 24 名健康年轻男性进行为期 7 天的口服 DHEA（150 mg b.d.）或安慰剂疗程的治疗。使用视觉模拟量表（VAS）测量主观情绪和记忆力。测量唾液样本中的皮质醇浓度。在情景记忆测试中检索期间记录了 ERP。低分辨率脑电磁断层扫描（LORETA）用于识别参与认知任务的大脑区域。结果：DHEA 给药导致夜间皮质醇浓度降低，并改善 VAS 情绪和记忆力。给予 DHEA 后，情景记忆测试中的回忆准确性显着提高。 LORETA 揭示了安慰剂后海马体的显着激活与成功的情景记忆检索相关。 DHEA 修改了与检索相关的 ERP，并导致前扣带皮层 (ACC) 早期差异激活的趋势。结论：DHEA 治疗可改善记忆力和情绪，并降低皮质醇谷值。 DHEA 的作用似乎是通过神经元招募类固醇敏感的 ACC 来发挥作用，而 ACC 可能参与海马前记忆处理。这些研究结果与众不同，首次表明 DHEA 对健康年轻男性的记忆力有如此有益的影响。
Rationale: Dehydroepiandrosterone (DHEA) has been reported to enhance cognition in rodents, although there are inconsistent findings in humans. Objectives: The aim of this study was to investigate the effects of DHEA administration in healthy young men on episodic memory and its neural correlates utilising an event-related potential (ERP) technique. Methods: Twenty-four healthy young men were treated with a 7-day course of oral DHEA (150 mg b.d.) or placebo in a double blind, random, crossover and balanced order design. Subjective mood and memory were measured using visual analogue scales (VASs). Cortisol concentrations were measured in saliva samples. ERPs were recorded during retrieval in an episodic memory test. Low-resolution brain electromagnetic tomography (LORETA) was used to identify brain regions involved in the cognitive task. Results: DHEA administration led to a reduction in evening cortisol concentrations and improved VAS mood and memory. Recollection accuracy in the episodic memory test was significantly improved following DHEA administration. LORETA revealed significant hippocampal activation associated with successful episodic memory retrieval following placebo. DHEA modified ERPs associated with retrieval and led to a trend towards an early differential activation of the anterior cingulate cortex (ACC). Conclusions: DHEA treatment improved memory recollection and mood and decreased trough cortisol levels. The effect of DHEA appears to be via neuronal recruitment of the steroid sensitive ACC that may be involved in pre-hippocampal memory processing. These findings are distinctive, being the first to show such beneficial effects of DHEA on memory in healthy young men.