Factors associated with malaria infection among children after distribution of PBO-pyrethroid synergist-treated nets and indoor residual spraying in north-western Tanzania.
Factors associated with malaria infection among children after distribution of PBO-pyrethroid synergist-treated nets and indoor residual spraying in north-western Tanzania.
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DOI：
10.1371/journal.pone.0295800
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
经过十年的成功控制，疟疾再次上升。坦桑尼亚的疟疾患病率从2017年的7%上升到2022年的8%，在坦桑尼亚西北部的卡盖拉地区达到18%。Muleba区卡盖拉的疟疾病媒对拟除虫菊酯具有高度抗药性。本文的目的是探索与Muleba地区6个月至14岁儿童疟疾感染率相关的因素，该地区于2015年首次在试验条件下分发了长效驱虫蚊帐（LLIN），该蚊帐结合了拟除虫菊酯类杀虫剂和增效醚（PBO），可抵消蚊子的抗药性。该试验是一项社区随机对照试验，其中2015年至2017年每年（6月和12月）在Muleba进行两次疟疾流行率横断面家庭调查。在这项研究中，我们只对12月的调查进行了二次数据分析。多水平Poisson回归分析用于评估与疟疾感染相关的因素。共有10，941名儿童和4，611个家庭参与了这项研究。2015年、2016年和2017年的总体疟疾患病率分别为35.8%、53.3%和54.4%。生活在标准LLIN而不是新型PBO LLIN地区，是5岁以上的男孩，生活在屋檐敞开的房子里，生活在没有IRS的房子里，户主没有受过正规教育，社会经济地位较低和调查年份与疟疾感染风险增加有关。使用PBO长效驱虫蚊帐降低了感染疟疾的风险。然而，在杀虫剂抗药性地区，如住房改善，采取额外措施可进一步减少疟疾感染。
After a decade of successful control, malaria is on the rise again. The prevalence of malaria in Tanzania has increased from 7% in 2017 to 8% in 2022 and reached 18% in Kagera region in the North West of Tanzania. Malaria vectors in Muleba district Kagera have high level of pyrethroid resistance. The aim of this paper is to explore factors associated with malaria infection prevalence in children aged 6 months to 14 years in Muleba, where Long Lasting Insecticidal Net (LLIN) combining a pyrethroid insecticide and synergist piperonyl butoxide (PBO) that counteract resistance in the mosquitoes, was first distributed under trial conditions in 2015. The trial was a community randomized control in which there were two malaria prevalence cross-sectional household surveys each year (June and December) from 2015 to 2017 in Muleba. In this study we conducted a secondary data analysis of the December surveys only. Multilevel Poisson regression analysis was used to assess factors associated with malaria infection. A total of 10,941 children and 4,611 households were included in this study. Overall malaria prevalence was 35.8%, 53.3% and 54.4% in the year 2015, 2016 and 2017 respectively. Living in an area with standard LLIN as opposed to the novel PBO synergist LLIN, being a male child, above 5 years of age, living in a house with open eaves, living in house without IRS, having head of household with no formal education, lower socioeconomic status and survey year were associated with increased risk of malaria infection. Using PBO LLIN reduced the risk of malaria infection. However, additional measures could further reduce malaria infection in areas of insecticide resistance such as housing improvement.
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影响因子：
15.8
作者：
Katureebe A;Zinszer K;Arinaitwe E;Rek J;Kakande E;Charland K;Kigozi R;Kilama M;Nankabirwa J;Yeka A;Mawejje H;Mpimbaza A;Katamba H;Donnelly MJ;Rosenthal PJ;Drakeley C;Lindsay SW;Staedke SG;Smith DL;Greenhouse B;Kamya MR;Dorsey G
通讯作者：
Dorsey G
DOI：
10.1371/journal.pgph.0000453
发表时间：
2022
期刊：
PLOS global public health
影响因子：
--
作者：
通讯作者：
--
DOI：
10.4269/ajtmh.2010.10-0242
发表时间：
2010-10-01
影响因子：
3.3
作者：
Fornadel, Christen M.;Norris, Laura C.;Norris, Douglas E.
通讯作者：
Norris, Douglas E.
DOI：
10.1016/s0035-9203(00)90103-2
发表时间：
2000-07-01
影响因子：
2.2
作者：
Howard, SC;Omumbo, J;Snow, RW
通讯作者：
Snow, RW
DOI：
10.4269/ajtmh.2003.68.121
发表时间：
2003-04-01
影响因子：
3.3
作者：
Hawley, WA;Phillips-Howard, PA;Hightower, AW
通讯作者：
Hightower, AW