Intravenous chemotherapy for resected gastric cancer: meta-analysis of randomized controlled trials
Intravenous chemotherapy for resected gastric cancer: meta-analysis of randomized controlled trials
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DOI：
10.3748/wjg.v8.i6.1023
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发表时间：
2002-12-01
影响因子：
4.3
通讯作者：
Li, YP
中科院分区：
文献类型：
--
作者：
Hu, JK;Chen, ZX;Li, YP
目的：评价不同静脉化疗方案对胃切除术后胃癌患者的安全性和有效性。方法：对所有相关随机对照试验（rct）进行荟萃分析。当时的语言仅限于中文和英文。随机对照试验来源于Medline和Embase（1980-2001/4）和中国生物医学数据库（1990-2001/1）。同时检查文献参考文献。我们纳入随机和准随机试验，比较确诊胃癌患者行胃切除术后静脉化疗与单纯手术的疗效。选择标准：随机或准随机试验，并有随访结果。试验可以是双盲、单盲或非盲；化疗组在胃切除术后给予静脉化疗，不进行新辅助化疗、腹腔热灌注、放疗或化学免疫治疗；对照组包括单纯行胃切除术的患者。提取以下数据：随访结束时生存和死亡人数；静脉化疗的不同药物和剂量；化疗组与对照组基线；严重不良事件；统计考虑；成本效益分析。采用Cochrane协作网提供的RevMan4.1软件进行统计分析。的p值
AIM: To assess the safety and efficacy of different intravenous chemotherapeutic regimens in patients with gastric carcinomas who had undergone gastrectomy.METHODS: A meta-analysis of all the relevant randomized controlled trials (RCTs) was performed. Language was restricted to Chinese and English. RCTs were identified from Medline and Embase (1980-2001/4), and Chinese Biomedicine Database (1990-2001/1). Literature references were checked at the same time. We included randomized and quasi-randomized trials comparing the efficacy of intravenous chemotherapy after gastrectomy with that of surgery alone in patients with confirmed gastric carcinomas who had undergone gastrectomy. Selection criteria were: randomized or quasi-randomized trials with following-up results. Trials could be double-blind, single-blind or not blind; Chemotherapy groups were given intravenous chemotherapy after gastrectomy without neo-adjuvant chemotherapy, intraperitoneal hyperthermic perfusion, radiotherapy or chemoimmunotherapy; Controlled group included those receiving gastrectomy alone. The following data were extracted: the number of survival and death by the end of the follow-up; the different agents and doses of the intravenous chemotherapy; the baseline of the chemotherapy group and the controlled arm; the serious adverse events; the statistical consideration; cost-effectiveness analysis. The statistical analysis was performed by RevMan4.1 software which was provided by the Cochrane Collaboration. A Pvalue of