IMMUNIZATION OF GUINEA-PIGS AND CATTLE AGAINST TICKS
IMMUNIZATION OF GUINEA-PIGS AND CATTLE AGAINST TICKS
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DOI：
10.1038/280491a0
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发表时间：
1979-01-01
期刊：
影响因子：
64.8
通讯作者：
HUMPHREYS, SJ
中科院分区：
文献类型：
--
作者：
ALLEN, JR;HUMPHREYS, SJ
硬蜱附着在宿主的皮肤上，并在那里停留几天，充血并间歇性地将唾液分泌到宿主1中。有几种硬蜱将病原微生物及其唾液传播到宿主体内，硬蜱传播的疾病具有重要的经济意义，特别是在亚热带和热带地区的牛身上2。由于抗杀螨剂菌株的出现，用化学杀螨剂控制牛虱变得越来越困难。本文报道了一种明显新颖的豚鼠和牛的免疫防治方法。用从肠道和其他内脏提取的抗原免疫寄主，这些抗原是从部分喂食的扁虱体内提取的。随后寄生在这些宿主上的扁虱表现出显著的摄食和繁殖性能下降。这些实验结果提出了通过对宿主进行适当的免疫来控制某些牛蜱物种的理论可能性。
IXODID TICKS attach to the skin of their host and remain there for several days, engorging on blood and intermittently passing salivary secretions into the host1. Several species of Ixodid ticks transmit pathogenic microorganisms along with their saliva into the host, and tick-borne diseases are of great economic importance, particularly in cattle in subtropical and tropical areas2. The control of cattle ticks by chemical acaricides has become increasingly difficult due to the emergence of acaricide-resistant strains of ticks3. An apparently novel immunological method of tick control in guinea pigs and cattle is reported here. Hosts were immunised with antigens extracted from the gut and other internal organs of partially fed ticks. Ticks which subsequently parasitised these hosts showed significantly reduced feeding and reproductive performance. These experimental results raise the theoretical possibility of controlling some species of cattle ticks by appropriate immunisation of their hosts.