Sleep-disordered breathing in men with coronary artery disease
Sleep-disordered breathing in men with coronary artery disease
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DOI：
10.1378/chest.109.3.659
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发表时间：
1996-03-01
期刊：
影响因子：
9.6
通讯作者：
Eriksson, P
中科院分区：
文献类型：
--
作者：
Mooe, T;Rabben, T;Eriksson, P
目的：研究男性冠心病患者睡眠呼吸暂停和夜间低氧血症的发生情况，并评估呼吸障碍与冠心病的关系。设计：病例对照研究。从因心绞痛行冠状动脉造影的男性中随机选择病例。对照组是年龄匹配的，并从人口登记处选择，脉搏血氧仪，口鼻呼吸器，体位指示器，身体和呼吸运动的记录被用来量化去饱和度和呼吸暂停。设置：Norrland大学医院，北方瑞典的转诊中心。受试者：142名心绞痛和血管造影证实的CAD男性和50名无已知心脏病的对照组。主要结果测量：每小时睡眠中动脉血氧饱和度下降4%或以上的次数，即血氧饱和度下降指数（ODI），以及每小时睡眠中呼吸暂停或呼吸不足的次数，即呼吸暂停低通气指数（AHI）。患有CAD的男性有较高的睡眠呼吸障碍发生率，ODI ≥ 5，39%（n=55），或AHI ≥ 10，37%（n=50），对照组为22%（n=11，p
Objective: To examine the occurrence of sleep apnea and nocturnal hypoxemia in men with symtomatic coronary artery disease (CAD) and to evaluate the relationship between disordered breathing and coronary artery disease.Design: Case-control study. Cases were randomly selected from men undergoing coronary angiography because of angina pectoris. Controls were age matched and selected from the population registry, Pulse oximetry, oronasal thermistors, body position indicator, and recording of body and respiratory movements were used to quantify desaturations and apneas.Setting: Norrland University Hospital, a referral center for northern Sweden.Subjects: One hundred forty-two men with angina pectoris and angiographically verified CAD and 50 controls without known heart disease.Main outcome measures: The number of arterial oxygen desaturations of 4% or more per hour of sleep, oxygen desaturation index (ODI), and the number of apneas or hypopneas per hour of sleep, apnea-hypopnea index (AHI).Results: Men with CAD had a high occurrence of sleep-disordered breathing measured as ODI of 5 or more, 39% (n=55), or AHI of 10 or more, 37% (n=50), while the same proportions in controls were 22% (n=11, p