Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging
Structural Brain Abnormalities in Patients with Primary Open-Angle Glaucoma: A Study with 3T MR Imaging
复制标题
原发性开角型青光眼患者的大脑结构异常：一项 3T MR 成像研究
DOI：
10.1167/iovs.12-9893
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发表时间：
2013-01-01
影响因子：
4.4
通讯作者：
Gong, Qiyong
中科院分区：
文献类型：
--
作者：
Chen, Wei W.;Wang, Ningli;Gong, Qiyong
目的。方法对15例双眼晚期开角型青光眼患者和15例年龄、性别与研究组年龄、性别相匹配的正常对照组进行临床观察。用光学相干断层扫描(OCT)测量视网膜神经纤维层(RNFL)厚度。采用磁共振成像(MRI)三维磁化准备快速梯度回波序列(3D-MP-RAGE)和优化体素形态计量学(VBM)测量视神经、视交叉横截面积和脑灰质体积。结果：POAG组与对照组比较，P<；0.001)双侧舌回、扣带回、中央后回、额上回、额下回、滚盖部灰质体积减少，右侧楔叶、右侧枕下回、左侧中央旁小叶、右侧缘上回灰质体积减少。研究组患者双侧颞中回、顶下回、角回灰质体积明显增大，左侧顶上回、楔前回、枕中回灰质体积明显增大。POAG组视神经横截面积、视交叉横截面积和视神经纤维层厚度均显著减少。结论：POAG患者三维MRI显示视皮层以外的中枢神经系统广泛异常。(投资眼科VS科学。2013年；54：545-554)doi：10.1167/iovs.12-9893
PURPOSE. We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG).METHODS. The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber layer (RNFL) thickness was measured by optical coherence tomography (OCT). Using a 3-dimensional magnetization-prepared rapid gradient-echo sequence (3D-MP-RAGE) of magnetic resonance imaging (MRI) and optimized voxel-based morphometry (VBM), we measured the cross-sectional area of the optic nerve and optic chiasm, and the gray matter volume of the brain.RESULTS. Patients in the POAG group compared to the subjects in the control group showed a significant (P < 0.001) decrease in the bilateral gray-matter volume in the lingual gyrus, calcarine gyrus, postcentral gyrus, superior frontal gyrus, inferior frontal gyrus, and rolandic operculum, as well as in the right cuneus, right inferior occipital gyrus, left paracentral lobule, and right supramarginal gyrus. Patients in the study group showed a significant increase in the bilateral gray matter volume in the middle temporal gyrus, inferior parietal gyrus, and angular gyrus, and in the left gray matter volume in the superior parietal gyrus, precuneus, and middle occipital gyrus. In addition, the cross-sectional area of the optic nerve and optic chiasm, and RNFL thickness were significantly decreased in the POAG group.CONCLUSIONS. In patients with POAG, three-dimensional MRI revealed widespread abnormalities in the central nervous system beyond the visual cortex. (Invest Ophthalmol Vis Sci. 2013;54:545-554) DOI:10.1167/iovs.12-9893