Phagocytosis-like cell engulfment by a planctomycete bacterium
Phagocytosis-like cell engulfment by a planctomycete bacterium
复制标题
DOI：
10.1038/s41467-019-13499-2
复制
发表时间：
2019-12-11
影响因子：
16.6
通讯作者：
Ishida, Ken-ichiro
中科院分区：
文献类型：
--
作者：
Shiratori, Takashi;Suzuki, Shigekatsu;Ishida, Ken-ichiro
吞噬作用是真核生物的一个关键特征，从单细胞原生生物到动物都有，它使真核生物能够以其他生物为食。它也可能是内共生的驱动力，内共生是a-变形菌和蓝细菌分别进化成线粒体和质体的过程。在这里，我们描述了一种浮游菌细菌，'无定形的Escheridatus Uab'，它能够通过类似吞噬作用的机制吞噬其他细菌和小的真核细胞。通过光学和电子显微镜的观察表明，这种细菌在特定的隔间中捕获猎物细胞。除了编码肌动蛋白样蛋白的基因之外，对'Ca. Uab amorphum的基因组序列没有显示任何与真核吞噬基因同源的基因，这表明这种微生物的细胞吞噬可能与真核吞噬不同源。这种“噬菌”细菌的发现扩展了我们对原核生物细胞复杂性的理解，并可能与真核细胞的起源有关。
Phagocytosis is a key eukaryotic feature, conserved from unicellular protists to animals, that enabled eukaryotes to feed on other organisms. It could also be a driving force behind endosymbiosis, a process by which a-proteobacteria and cyanobacteria evolved into mitochondria and plastids, respectively. Here we describe a planctomycete bacterium, 'Candidatus Uab amorphum', which is able to engulf other bacteria and small eukaryotic cells through a phagocytosis-like mechanism. Observations via light and electron microscopy suggest that this bacterium digests prey cells in specific compartments. With the possible exception of a gene encoding an actin-like protein, analysis of the 'Ca. Uab amorphum' genomic sequence does not reveal any genes homologous to eukaryotic phagocytosis genes, suggesting that cell engulfment in this microorganism is probably not homologous to eukaryotic phagocytosis. The discovery of this "phagotrophic" bacterium expands our understanding of the cellular complexity of prokaryotes, and may be relevant to the origin of eukaryotic cells.